4-Isobutylmorpholine

Base Information

• Chemical Name: 4-Isobutylmorpholine
• CAS No.: 10315-98-7
• Molecular Formula: C8H17 N O
• Molecular Weight: 143.229
• Hs Code.: 2934999090
• European Community (EC) Number: 233-696-1
• NSC Number: 158332
• UNII: 4ED4U4AW7A
• DSSTox Substance ID: DTXSID30145675
• Nikkaji Number: J208.628J
• Wikidata: Q83010245
• Mol file: 10315-98-7.mol

Synonyms:4-Isobutylmorpholine;N-Isobutylmorpholine;10315-98-7;4-(2-methylpropyl)morpholine;Morpholine, 4-(2-methylpropyl)-;Morpholine, 4-isobutyl-;4ED4U4AW7A;EINECS 233-696-1;NSC-158332;NSC158332;4-Isobutyl-morpholine;UNII-4ED4U4AW7A;C(C(C)C)N1CCOCC1;SCHEMBL200033;DTXSID30145675;MFCD00023382;AKOS022299895;NSC 158332;CS-0445223;FT-0636677;I0254;D91109

Chemical Property of 4-Isobutylmorpholine

Chemical Property:

• Vapor Pressure: 0.939mmHg at 25°C
• Melting Point: -9.9°C
• Refractive Index: n20/D 1.439
• Boiling Point: 179.5°Cat760mmHg
• Flash Point: 49.8°C
• PSA: 12.47000
• Density: 0.897g/cm³
• LogP: 0.91250
• XLogP3: 1.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 143.131014166
• Heavy Atom Count: 10
• Complexity: 87.3

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-Isobutylmorpholine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 10-36/37/38
• Safety Statements: 16-26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CN1CCOCC1

Technology Process of 4-Isobutylmorpholine

There total 10 articles about 4-Isobutylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-(2-methyl-1-propenyl)morpholine (2403-55-6) → N-isobutylmorpholine (10315-98-7)

Guidance literature:

With sodium tetrahydroborate; hydrogen; nickel dichloride; In isopropyl alcohol; at 50 ℃; for 5h; under 760.051 Torr;

DOI:10.1134/S1070363214110036

Reference yield: 79.0%

morpholine (110-91-8,99108-56-2) + isobutyryl chloride (513-36-0) → N-isobutylmorpholine (10315-98-7)

Guidance literature:

morpholine; With potassium carbonate; In tetrahydrofuran; at 20 ℃; for 0.25h;

isobutyryl chloride; In tetrahydrofuran; at 20 ℃; for 48h;

DOI:10.1080/14786410802090359

Reference yield: 71.0%

morpholine (110-91-8,99108-56-2) + 2-iodo-propane (75-30-9) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → N-isobutylmorpholine (10315-98-7)

Guidance literature:

With acetic acid; zinc; copper(l) iodide; In water; dimethyl sulfoxide; at 30 ℃; for 2h;

DOI:10.1016/j.tetlet.2005.08.139

upstream raw materials:

morpholine

isobutyraldehyde

4-(2-methyl-1-propenyl)morpholine

2,5-dihydrofuran