4-(Dimethylamino)phenol

Base Information

• Chemical Name: 4-(Dimethylamino)phenol
• CAS No.: 619-60-3
• Molecular Formula: C8H11NO
• Molecular Weight: 137.181
• Hs Code.: 2922299090
• European Community (EC) Number: 210-604-8
• UNII: X387L5559O
• DSSTox Substance ID: DTXSID70210932
• Nikkaji Number: J135.646A
• Wikipedia: 4-Dimethylaminophenol
• Wikidata: Q229950
• Metabolomics Workbench ID: 154346
• ChEMBL ID: CHEMBL3707216
• Mol file: 619-60-3.mol

Synonyms:4-(dimethylamino)phenol;4-dimethylaminophenol;4-dimethylaminophenol hydrochloride;4-dimethylaminophenol oxalate (1:1)

Chemical Property of 4-(Dimethylamino)phenol

Chemical Property:

• Vapor Pressure: 0.00789mmHg at 25°C
• Melting Point: 138-141℃
• Refractive Index: 1.5560 (estimate)
• Boiling Point: 259.7 °C at 760 mmHg
• PKA: 10.11±0.13(Predicted)
• Flash Point: 135.6 °C
• PSA: 23.47000
• Density: 1.089 g/cm³
• LogP: 1.45820
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 137.084063974
• Heavy Atom Count: 10
• Complexity: 95.4

Purity/Quality:

99%, ^*data from raw suppliers

4-(Dimethylamino)phenol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Amino Phenols
• Canonical SMILES: CN(C)C1=CC=C(C=C1)O

Technology Process of 4-(Dimethylamino)phenol

There total 68 articles about 4-(Dimethylamino)phenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 4-nitro-phenol (100-02-7,78813-13-5,89830-32-0) → 4-(N,N-dimethylamino)phenol (619-60-3)

Guidance literature:

With sodium carbonate; In water; dimethyl sulfoxide; at 130 ℃; for 15h; Schlenk technique; Sealed tube; Green chemistry;

DOI:10.1016/j.jcat.2019.06.022

Reference yield: 96.0%

methanol (67-56-1) + 4-amino-phenol (123-30-8) → 4-(N,N-dimethylamino)phenol (619-60-3)

Guidance literature:

With C₁₅H₂₉IrN₄⁽²⁺⁾*2I^(1-); at 120 ℃; for 17h; Inert atmosphere; Schlenk technique; Sealed tube;

DOI:10.1055/s-0037-1610252

Reference yield: 92.0%

4-(dimethylamino)benzene-boronic acid (28611-39-4) → 4-(N,N-dimethylamino)phenol (619-60-3)

Guidance literature:

With potassium phosphate; hydrazine hydrate; at 80 ℃; for 8h;

upstream raw materials:

tetrahydrofuran

diethyl ether

phenyllithium

4-methoxy-N,N-dimethylanilne

Downstream raw materials:

tetra-N-methyl-4,4'-(3-oxa-pentanediyldioxy)-di-aniline

methyl-carbamic acid-(4-dimethylamino-phenyl ester)

tetra-N-methyl-4,4'-pentanediyldioxy-di-aniline

4-Dimethylamino-3-isopropyl-phenol

Refernces

• 1、 Abuzalat, Osama,Alkordi, Mohamed H.,Baraka, Ahmad,Basuni, Mustafa,Tantawy, Hesham. "Designing bimetallic zeolitic imidazolate frameworks (ZIFs) for aqueous catalysis: Co/Zn- ZIF-8 as a cyclic-durable catalyst for hydrogen peroxide oxidative decomposition of organic dyes in water". . p. 6025 - 6036. Retrieved 2022/03/31.
• 2、 -. "Synthesis method of substituted phenol". . . Retrieved 2020/09/16.