N-Methylacetamide

Base Information

• Chemical Name: N-Methylacetamide
• CAS No.: 79-16-3
• Deprecated CAS: 1320-47-4
• Molecular Formula: C3H7NO
• Molecular Weight: 73.0947
• Hs Code.: 29241900
• European Community (EC) Number: 201-182-6
• NSC Number: 747
• UNII: V0T777481M
• DSSTox Substance ID: DTXSID0047167
• Nikkaji Number: J1.964J
• Wikidata: Q12871952
• Metabolomics Workbench ID: 122324
• ChEMBL ID: CHEMBL11544
• Mol file: 79-16-3.mol

Synonyms:N-methyl acetamide;N-methylacetamide;N-methylacetamide sodium salt

Chemical Property of N-Methylacetamide

Chemical Property:

• Appearance/Colour: colourless liquid or solid
• Vapor Pressure: 12-3680Pa at 15-113℃
• Melting Point: 26-28 °C(lit.)
• Refractive Index: n20/D 1.433(lit.)
• Boiling Point: 206 °C at 760 mmHg
• PKA: 16.61±0.46(Predicted)
• Flash Point: 109.1 °C
• PSA: 29.10000
• Density: 0.87 g/cm³
• LogP: 0.14320
• Storage Temp.: Store below +30°C.
• Solubility.: miscible with ethanol, ether, acetone, water, chloroform, benzene
• Water Solubility.: soluble
• XLogP3: -1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 73.052763847
• Heavy Atom Count: 5
• Complexity: 42.2

Purity/Quality:

99% ^*data from raw suppliers

N-Methylacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 61
• Safety Statements: 53-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Nitrogen Compounds -> Other Nitrogen Compounds
• Canonical SMILES: CC(=O)NC
• Uses: N-Methylacetamide is used as a chemical intermediate in the production of life science, agrochemicals, electronic materials and construction materials. It is also used as a solvent, in electrochemistry.

Technology Process of N-Methylacetamide

There total 123 articles about N-Methylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

acetic acid (64-19-7,77671-22-8) + methylamine (74-89-5) → N-methyl-acetamide (79-16-3)

Guidance literature:

With aluminum oxide; at 70 ℃; for 0.416667h; Neat (no solvent);

DOI:10.1039/c2gc16020j

Reference yield: 96.3%

ethyl acetate (141-78-6) + methylamine (74-89-5) → N-methyl-acetamide (79-16-3)

Guidance literature:

With tetramethylammonium bromide; In water; at 80 - 110 ℃; for 10h; Reagent/catalyst; Autoclave; Large scale;

Reference yield: 87.0%

2,5-diaza-3,4-dimethyl-2,4-hexadiene (4381-85-5) → N-methyl-acetamide (79-16-3) + methyl isocyanate (593-75-9,685498-28-6)

Guidance literature:

With oxygen; rose bengal; In acetonitrile; at 13 ℃; for 9h; Irradiation;

DOI:10.1021/jo00027a041

upstream raw materials:

acetamide

methylamine hydrochloride

methylamine sulphate

potassium methyl sulfate

Downstream raw materials:

acetophenone

N-methyl-N-trimethylsilylacetamide

N-methyldiacetamide

1,5-dimethyl-1H-tetrazole

Refernces

• 1、 Nielsen, John,Tung, Truong Thanh. "Amide bond formation in aqueous solution: Direct coupling of metal carboxylate salts with ammonium salts at room temperature". supporting information. p. 10073 - 10080. Retrieved 2021/12/10.
• 2、 Ball, Zachary T.,Wang, Haopei. "A photochemical C=C cleavage process: Toward access to backbone N-formyl peptides". . p. 2932 - 2938. Retrieved 2022/01/12.