1,2-Diphenyl-2-propanol

Base Information

• Chemical Name: 1,2-Diphenyl-2-propanol
• CAS No.: 5342-87-0
• Molecular Formula: C15H16 O
• Molecular Weight: 212.291
• Hs Code.: 2906299090
• European Community (EC) Number: 635-149-6
• NSC Number: 3671
• DSSTox Substance ID: DTXSID001031541
• Nikkaji Number: J781.812B
• Mol file: 5342-87-0.mol

Synonyms:1,2-Diphenyl-2-propanol;1,2-diphenylpropan-2-ol;5342-87-0;Benzeneethanol, .alpha.-methyl-.alpha.-phenyl-;1,2-diphenyl-propan-2-ol;NSC3671;alpha-Methyl-alpha-phenylbenzeneethanol;Benzeneethanol, alpha-methyl-alpha-phenyl-;Methylphenylbenzylcarbinol;1,2-Diphenyl-2-propanol #;SCHEMBL3583487;1-methyl-1,2-diphenyl-ethanol;DTXSID001031541;NSC 3671;NSC-3671;AKOS009157468

Chemical Property of 1,2-Diphenyl-2-propanol

Chemical Property:

• Vapor Pressure: 0.000949mmHg at 25°C
• Refractive Index: 1.5705 (estimate)
• Boiling Point: 290.5°Cat760mmHg
• Flash Point: 130.9°C
• PSA: 20.23000
• Density: 1.073g/cm³
• LogP: 3.13680
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 3
• Exact Mass: 212.120115130
• Heavy Atom Count: 16
• Complexity: 202

Purity/Quality:

99% ^*data from raw suppliers

1,2-DIPHENYLPROPAN-2-OL 95.00% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36
• Safety Statements: 26

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Classes -> Other Aromatic Compounds
• Canonical SMILES: CC(CC1=CC=CC=C1)(C2=CC=CC=C2)O

Technology Process of 1,2-Diphenyl-2-propanol

There total 43 articles about 1,2-Diphenyl-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

acetophenone (98-86-2) + benzylmagnesium chloride (6921-34-2) → 1,2-diphenylpropane-2-ol (5342-87-0)

Guidance literature:

In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/acs.orglett.9b01959

Reference yield: 99.0%

benzaldehyde, hydrazone (5281-18-5) + acetophenone (98-86-2) → 1,2-diphenylpropane-2-ol (5342-87-0)

Guidance literature:

With potassium phosphate; Fe(1,2-bis(dimethylphosphino)ethane)2Cl₂; cesium fluoride; In tetrahydrofuran; at 20 ℃; for 24h; Reagent/catalyst; Solvent; Catalytic behavior; Glovebox; Inert atmosphere;

DOI:10.1021/acs.orglett.8b01391

Reference yield: 96.0%

2,2'-(1-phenylethane-1,1-diyl)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane) (428819-24-3) + benzyl bromide (100-39-0) → 1,2-diphenylpropane-2-ol (5342-87-0)

Guidance literature:

2,2'-(1-phenylethane-1,1-diyl)bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolane); With methyllithium; In tetrahydrofuran; 1,2-dimethoxyethane; at -78 ℃; for 0.166667h; Inert atmosphere; Schlenk technique;

benzyl bromide; In tetrahydrofuran; 1,2-dimethoxyethane; at -78 - 0 ℃; for 1h; Inert atmosphere; Schlenk technique;

With dihydrogen peroxide; sodium hydroxide; In tetrahydrofuran; 1,2-dimethoxyethane; water; at 23 ℃; for 2h; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.tetlet.2014.03.135

upstream raw materials:

phenyl benzyl ketone

methyl magnesium iodide

2-hydroxy-1,2-diphenyl-propylmercury ⁽¹⁺⁾; chloride

phenylmagnesium bromide

Downstream raw materials:

1,2-diphenylpropene

1,2 diphenyl 2 propylamine

(E)-1,2-diphenylpropene

cis-α-methylstilbene

Refernces

• 1、 Wang, Yi-Zhan,Liu, Qi,Cheng, Liang,Yu, Song-Chen,Liu, Li,Li, Chao-Jun. "Addition reactions of organic carbanion equivalents via hydrazones in water". supporting information. . Retrieved 2021/01/11.
• 2、 Ganiu, Moshood O.,Cleveland, Alexander H.,Paul, Jarrod L.,Kartika, Rendy. "Triphosgene and DMAP as Mild Reagents for Chemoselective Dehydration of Tertiary Alcohols". supporting information. p. 5611 - 5615. Retrieved 2019/08/01.