ethyl 2,5-diphenyl-1H-pyrrole-3-carboxylate

Base Information

• Chemical Name: ethyl 2,5-diphenyl-1H-pyrrole-3-carboxylate
• CAS No.: 65474-26-2
• Molecular Formula: C19H17 N O2
• Molecular Weight: 291.349
• Hs Code.: 2933990090
• Mol file: 65474-26-2.mol

Synonyms:Pyrrole-3-carboxylicacid, 2,5-diphenyl-, ethyl ester (7CI); NSC 306837

Chemical Property of ethyl 2,5-diphenyl-1H-pyrrole-3-carboxylate

Chemical Property:

• Vapor Pressure: 2.57E-11mmHg at 25°C
• Boiling Point: 530°C at 760 mmHg
• Flash Point: 274.3°C
• PSA: 42.09000
• Density: 1.152g/cm³
• LogP: 4.52540

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2,5-diphenyl-1H-pyrrole-3-carboxylate

There total 23 articles about ethyl 2,5-diphenyl-1H-pyrrole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

ethyl 2-benzoyl-4-oxo-4-phenylbutanoate (29113-48-2) → ethyl 2,5-diphenyl-1H-pyrrole-3-carboxylate (65474-26-2)

Guidance literature:

With ammonia; In acetic acid; at 80 ℃; for 1h; Heating;

Reference yield: 70.0%

(E)-4-methyl-N′-(1-phenylethylidene)benzenesulfonohydrazide (62460-99-5) + ethyl (Z)-3-amino-3-phenylacrylate (53256-19-2) → ethyl 2,5-diphenyl-1H-pyrrole-3-carboxylate (65474-26-2)

Guidance literature:

With tert.-butylhydroperoxide; iodine; In dimethyl sulfoxide; at 20 ℃; for 24h; Irradiation; Inert atmosphere;

DOI:10.1021/acs.joc.8b00878

Reference yield: 63.0%

1-azidostyrene (16717-64-9) + ethyl 3-oxo-3-phenylpropionate (94-02-0) → ethyl 2,5-diphenyl-1H-pyrrole-3-carboxylate (65474-26-2)

Guidance literature:

With manganese(III) triacetate dihydrate; acetic acid; In methanol; at 40 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ol802120u

upstream raw materials:

ethyl 2-benzoyl-4-oxo-4-phenylbutanoate

ammonium acetate

N-benzyl-thiobenzimidic acid methyl ester

propynoic acid ethyl ester

Downstream raw materials:

4-Bromo-2,5-diphenyl-1H-pyrrole-3-carboxylic acid

3,4-Dibromo-2,5-diphenyl-1H-pyrrole

2,5-diphenyl-1H-pyrrole

ethyl 4-nitro-2,5-diphenyl-1H-pyrrole-3-carboxylate

Refernces

• 1、 Kumar Reddy, N. Naresh,Rawat, Deepa,Adimurthy, Subbarayappa. "Visible-Light-Induced C (sp3)-H Functionalization of Tosylhydrazones: Synthesis of Polysubstituted Pyrroles under Metal-Free Conditions". . p. 9412 - 9421. Retrieved 2018/07/30.
• 2、 Loy, Nicole S. Y.,Choi, Subin,Kim, Sunggak,Park, Cheol-Min. "The synthesis of pyrroles and oxazoles based on gold α-imino carbene complexes". . p. 7336 - 7339. Retrieved 2016/06/14.