5-Methoxy-quinazoline-2,4-diamine

Base Information

• Chemical Name: 5-Methoxy-quinazoline-2,4-diamine
• CAS No.: 27018-21-9
• Molecular Formula: C₉H₁₀N₄O
• Molecular Weight: 190.205
• Hs Code.: 2933990090
• Mol file: 27018-21-9.mol

Synonyms:5-methoxyquinazoline-2,4-diamine;5-Methoxy-2,4-chinazolindiamin;2,4-diamino-5-methoxyquinazoline;2,4-Quinazolinediamine,5-methoxy;5-Methoxy-2,4-diaminoquinazoline;

Chemical Property of 5-Methoxy-quinazoline-2,4-diamine

Chemical Property:

• Vapor Pressure: 1.49E-09mmHg at 25°C
• Melting Point: 208-209 °C
• Boiling Point: 484.8°Cat760mmHg
• PKA: 7.89±0.30(Predicted)
• Flash Point: 247°C
• PSA: 87.05000
• Density: 1.372g/cm³
• LogP: 1.96520
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

97% ^*data from raw suppliers

5-Methoxy-quinazoline-2,4-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Methoxy-quinazoline-2,4-diamine

There total 7 articles about 5-Methoxy-quinazoline-2,4-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

guanidine hydrogen carbonate (124-46-9,20734-13-8,100224-74-6,593-85-1,90332-86-8,3425-08-9) + 2-fluoro-6-methoxybenzonitrile (94088-46-7) → 5-methoxy-2,4-diaminoquinazoline (27018-21-9)

Guidance literature:

In N,N-dimethyl acetamide; at 140 - 142 ℃; for 10h;

Reference yield: 72.0%

guanidine carbonate (593-85-1,90332-86-8,3425-08-9) + methanol (67-56-1) + 2,6 difluorobenzonitrile (1897-52-5) → 5-methoxy-2,4-diaminoquinazoline (27018-21-9)

Guidance literature:

methanol; 2,6 difluorobenzonitrile; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 10h;

guanidine carbonate; In N,N-dimethyl acetamide; at 140 ℃; for 8h;

Reference yield: 44.0%

2-fluoro-6-methoxybenzonitrile (94088-46-7) + guanidine nitrate (113-00-8) → 5-methoxy-2,4-diaminoquinazoline (27018-21-9)

Guidance literature:

With sodium carbonate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl acetamide; at 125 ℃; for 3h;

DOI:10.1039/c5ra03510d

upstream raw materials:

guanidine hydrogen carbonate

2-fluoro-6-methoxybenzonitrile

2-amino-6-methoxybenzonitrile

chloroformamidine hydrochloride

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