4-FLUORO-6-INDAZOLECARBOXYLIC ACID METHYL ESTER

Base Information

• Chemical Name: 4-FLUORO-6-INDAZOLECARBOXYLIC ACID METHYL ESTER
• CAS No.: 885521-44-8
• Molecular Formula: C9H7FN2O2
• Molecular Weight: 194.16200

Synonyms:4-Fluoro-6-indazolecarboxylic acid methyl ester;

Chemical Property of 4-FLUORO-6-INDAZOLECARBOXYLIC ACID METHYL ESTER

Chemical Property:

• PSA: 54.98000
• LogP: 1.48860
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl4-Fluoro-1H-indazole-6-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Methyl 4-Fluoro-1H-indazole-6-carboxylate is used in preparation of N-Alkylated Indoles and Indazoles as ROR-gamma-T inhibitors.

Technology Process of 4-FLUORO-6-INDAZOLECARBOXYLIC ACID METHYL ESTER

There total 3 articles about 4-FLUORO-6-INDAZOLECARBOXYLIC ACID METHYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.3%

methanol (67-56-1) + 6-bromo-4-fluoro-1H-indazole (885520-23-0) + carbon monoxide (201230-82-2) → methyl 4-fluoro-1H-indazole-6-carboxylate (885521-44-8)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine; at 70 ℃; for 16h; under 2585.81 Torr;

Reference yield:

4-bromo-2,6-difluorobenzonitrile (123843-67-4) → methyl 4-fluoro-1H-indazole-6-carboxylate (885521-44-8)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 2 h / 90 °C / Inert atmosphere

2: hypophosphorous acid; isopentyl nitrite / ethanol / 0 - 20 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / 16 h / 70 °C / 2585.81 Torr

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; hypophosphorous acid; hydrazine hydrate; triethylamine; isopentyl nitrite; In ethanol;

Reference yield:

6-bromo-4-fluoro-1H-indazol-3-amine (1227912-19-7) → methyl 4-fluoro-1H-indazole-6-carboxylate (885521-44-8)

Guidance literature:

Multi-step reaction with 2 steps

1: hypophosphorous acid; isopentyl nitrite / ethanol / 0 - 20 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / 16 h / 70 °C / 2585.81 Torr

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; hypophosphorous acid; triethylamine; isopentyl nitrite; In ethanol;

upstream raw materials:

4-bromo-2,6-difluorobenzonitrile

6-bromo-4-fluoro-1H-indazol-3-amine

methanol

6-bromo-4-fluoro-1H-indazole

Downstream raw materials:

(1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-3-iodo-1H-indazol-6-yl)(3-methoxyazetidin-1-yl)methanone

methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-6-(3-methoxyazetidine-1-carbonyl)-1H-indazol-3-yl)-5-fluoro-2-methoxybenzoate

methyl 4-(1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-6-(3-methoxyazetidine-1-carbonyl)-1H-indazol-3-yl)-5-fluoro-2-hydroxybenzoate

4-(1-(2-chloro-6-(trifluoromethyl)benzyl)-4-fluoro-6-(3-methoxyazetidine-1-carbonyl)-1H-indazol-3-yl)-5-fluoro-2-hydroxybenzoic acid

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 885521-44-8 4-FLUORO-6-INDAZOLECARBOXYLIC ACID METHYL ESTER

Send

Send

Metric Ton KG G Pound L ML

Send

Send