(4R,5R)-2,2,7,7-Tetramethyl-2,7-disila-3,6-dioxaoctane-4,5-dicarboxylic acid dimethyl ester

Base Information

• Chemical Name: (4R,5R)-2,2,7,7-Tetramethyl-2,7-disila-3,6-dioxaoctane-4,5-dicarboxylic acid dimethyl ester
• CAS No.: 55659-11-5
• Molecular Formula: C12H26O6Si2
• Molecular Weight: 322.5
• Mol file: 55659-11-5.mol

Synonyms:(4R,5R)-2,2,7,7-Tetramethyl-2,7-disila-3,6-dioxaoctane-4,5-dicarboxylic acid dimethyl ester

Chemical Property of (4R,5R)-2,2,7,7-Tetramethyl-2,7-disila-3,6-dioxaoctane-4,5-dicarboxylic acid dimethyl ester

Chemical Property:

• Boiling Point: 279.4±40.0 °C(Predicted)
• PSA: 71.06000
• Density: 1.012±0.06 g/cm3(Predicted)
• LogP: 1.77260

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (4R,5R)-2,2,7,7-Tetramethyl-2,7-disila-3,6-dioxaoctane-4,5-dicarboxylic acid dimethyl ester

There total 1 articles about (4R,5R)-2,2,7,7-Tetramethyl-2,7-disila-3,6-dioxaoctane-4,5-dicarboxylic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + L-Tartaric acid (87-69-4,138508-61-9) + N,O-bis(trimethylsilyl)trifluoroacetamide (25561-30-2) → (2R,3R)-2,3-bis-trimethylsilanyloxy-succinic acid dimethyl ester (55659-11-5)

Guidance literature:

methanol; L-Tartaric acid; With boron trifluoride; at 65 ℃; for 0.333333h;

N,O-bis(trimethylsilyl)trifluoroacetamide; With pyridine; chloro-trimethyl-silane; at 70 ℃; for 2h;

DOI:10.1021/ac049919h

Reference yield: 100.0%

(2R,3R)-2,3-bis-trimethylsilanyloxy-succinic acid dimethyl ester (55659-11-5) + cis-2,6-bis(phenylmethyl)cyclohexanone (7382-09-4) → 6,10-bis(phenylmethyl)-1,4-dioxaspiro[4,5]-decane-(2R,3R)-dicarboxylic acid dimethyl ester (909914-55-2)

Guidance literature:

With trifluorormethanesulfonic acid; trimethylsilyl trifluoromethanesulfonate; at 60 ℃; for 48h;

DOI:10.1002/anie.200601722

Reference yield: 77.0%

(2R,3R)-2,3-bis-trimethylsilanyloxy-succinic acid dimethyl ester (55659-11-5) + o-phthalic dicarboxaldehyde (643-79-8) → 2,2'-(1,2-phenylene)bis[(4R,5R)-4,5-di(methoxycarbonyl)-1,3-dioxolane] (1078574-75-0)

Guidance literature:

(2R,3R)-2,3-bis-trimethylsilanyloxy-succinic acid dimethyl ester; o-phthalic dicarboxaldehyde; With boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃; for 0.25h;

With trifluorormethanesulfonic acid; In dichloromethane; at 0 - 20 ℃; Further stages.;

DOI:10.1007/s11172-007-0233-7

upstream raw materials:

methanol

L-Tartaric acid

N,O-bis(trimethylsilyl)trifluoroacetamide

Downstream raw materials:

6,10-bis(phenylmethyl)-1,4-dioxaspiro[4,5]-decane-(2R,3R)-dicarboxylic acid dimethyl ester

2,2'-(1,2-phenylene)bis[(4R,5R)-4,5-di(methoxycarbonyl)-1,3-dioxolane]

Refernces