AMINO-PEG12-T-BUTYL ESTER

Base Information

• Chemical Name: AMINO-PEG12-T-BUTYL ESTER
• CAS No.: 872340-65-3
• Molecular Formula: C₁₇H₃₅NO₇
• Molecular Weight: 365.467
• Mol file: 872340-65-3.mol

Synonyms:AMINO-PEG12-T-BUTYL ESTER;Amino-PEG12-t-butly ester;Amino-PEG13-t-butly ester;Amino-PEG36-t-butyl ester

Chemical Property of AMINO-PEG12-T-BUTYL ESTER

Chemical Property:

• PSA: 70.78000
• LogP: 1.41040
• Solubility.: Soluble in Water, DMSO, DMF, DCM

Purity/Quality:

98%Min ^*data from raw suppliers

H2N-PEG36-CH2CH2COOtBu min.97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Amino-PEG12-t-butyl ester is a aquepous soluble PEG linker containing an amino group (NH2) with a t-butyl protected carboxyl grou (Boc). The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Technology Process of AMINO-PEG12-T-BUTYL ESTER

There total 45 articles about AMINO-PEG12-T-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 1-azido-3,6,9,12,15,18-hexaoxahenicosan-21-oate (406213-76-1) → tert-butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate (1286281-32-0,872340-65-3)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃;

Reference yield: 96.0%

tert-butyl 1-azido-3,6,9,12-tetraoxapentadecan-15-oate (581066-04-8) → tert-butyl 3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]propanoate (581065-95-4,872340-65-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 1h;

Reference yield:

pentaethylene glycol (2615-15-8) → tert-butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate (1286281-32-0,872340-65-3)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 48 h / 20 °C

2: triethylamine / dichloromethane / 24 h / 20 °C

3: sodium azide / N,N-dimethyl-formamide / 72 h / 20 °C

4: hydrogen; acetyl chloride / methanol / 2 h

With sodium azide; hydrogen; sodium hydride; triethylamine; acetyl chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/ja2083015

upstream raw materials:

tert-butyl 1-azido-3,6,9,12-tetraoxapentadecan-15-oate

Tetraethylene glycol

tert-Butyl acrylate

tert-butyl 3-(2-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-ethoxy)propanoate

Downstream raw materials:

3-[2-(2-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}ethoxy)ethoxy]propanoic acid

C₄₁H₅₁F₂N₅O₇

12-{N-[(9H-fluoren-9-yl)methoxycarbonyl]amido}-4,7,10-trioxadodecanoic acid

pentafluorophenyl 1-bromo-2-oxo-6,9,12,15,18,21-hexaoxa-3-azatetracosan-24-oate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 872340-65-3 AMINO-PEG12-T-BUTYL ESTER

Send

Send

Metric Ton KG G Pound L ML

Send

Send