AMINO-PEG12-T-BUTYL ESTER

Base Information

• Chemical Name: AMINO-PEG12-T-BUTYL ESTER
• CAS No.: 872340-65-3
• Molecular Formula: C₁₇H₃₅NO₇
• Molecular Weight: 365.467
• Mol file: 872340-65-3.mol

Synonyms:AMINO-PEG12-T-BUTYL ESTER;Amino-PEG12-t-butly ester;Amino-PEG13-t-butly ester;Amino-PEG36-t-butyl ester

Chemical Property of AMINO-PEG12-T-BUTYL ESTER

Chemical Property:

• PSA: 70.78000
• LogP: 1.41040
• Solubility.: Soluble in Water, DMSO, DMF, DCM

Purity/Quality:

100% ^*data from raw suppliers

H2N-PEG36-CH2CH2COOtBu min.97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Description: Amino-PEG12-t-butyl ester is a aquepous soluble PEG linker containing an amino group (NH2) with a t-butyl protected carboxyl grou (Boc). The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Technology Process of AMINO-PEG12-T-BUTYL ESTER

There total 45 articles about AMINO-PEG12-T-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

tert-butyl 1-azido-3,6,9,12,15,18-hexaoxahenicosan-21-oate (406213-76-1) → tert-butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate (1286281-32-0,872340-65-3)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃;

Reference yield: 96.0%

tert-butyl 1-azido-3,6,9,12-tetraoxapentadecan-15-oate (581066-04-8) → tert-butyl 3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]propanoate (581065-95-4,872340-65-3)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 1h;

Reference yield:

pentaethylene glycol (2615-15-8) → tert-butyl 1-amino-3,6,9,12,15,18-hexaoxahenicosan-21-oate (1286281-32-0,872340-65-3)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran; mineral oil / 48 h / 20 °C

2: triethylamine / dichloromethane / 24 h / 20 °C

3: sodium azide / N,N-dimethyl-formamide / 72 h / 20 °C

4: hydrogen; acetyl chloride / methanol / 2 h

With sodium azide; hydrogen; sodium hydride; triethylamine; acetyl chloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; mineral oil;

DOI:10.1021/ja2083015

upstream raw materials:

tert-butyl 1-azido-3,6,9,12-tetraoxapentadecan-15-oate

tert-Butyl 3-(2-(2-(2-azidoethoxyl)ethoxy)ethoxy)propanoate

tert-butyl 1-hydroxy-3,6,9,12,15,18-hexaoxahenicosan-21-oate

tert-butyl 1-azido-3,6,9,12,15,18-hexaoxahenicosan-21-oate

Downstream raw materials:

3-(2-{2-[3-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanamido]ethoxy}ethoxy)propanoic acid

biotin-PEG₃-acid

pentafluorophenyl 1-bromo-2-oxo-6,9,12,15,18,21-hexaoxa-3-azatetracosan-24-oate

N-(24-bromo-23-oxo-4,7,10,13,16,19-hexaoxa-22-azatetracosan-1-oyl)-L-valyl-N-[2-(3-{[trans-4-({[(3R,5S,7R,8R)-8-hydroxy-7-{(1E,3E)-5-[(2S,3S,5R,6R)-5-{[(2Z,4S)-4-hydroxypent-2-enoyl]amino}-3,6-dimethyltetrahydro-2H-pyran-2-yl]-3-methylpenta-1,3-dien-1-yl}-1,6-dioxaspiro[2.5]oct-5-yl]acetyl}amino)cyclohexyl]oxy}-3-oxopropyl)phenyl]-L-alaninamide