Technology Process of 3-(1,1-diMethylethyl)dihydro-1,5-dioxo-(3R,7aR)-1H,3H-Pyrrolo[1,2-c]oxazole-7a(5H)-carboxaldehyde
There total 3 articles about 3-(1,1-diMethylethyl)dihydro-1,5-dioxo-(3R,7aR)-1H,3H-Pyrrolo[1,2-c]oxazole-7a(5H)-carboxaldehyde which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Methyl formate; (2R,5S)-2-t-butyl-1-aza-3-oxabicyclo<3.3.0>octane-4,8-dione;
With
1,3-dimethyl-2-imidazolidinone; chloro-trimethyl-silane; copper(l) chloride; lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -60 - 10 ℃;
for 0.5h;
Inert atmosphere;
With
trifluoroacetic acid;
In
water;
at 5 - 25 ℃;
for 3.66667h;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: methanesulfonic acid / diethylene glycol dimethyl ether; toluene / 14.5 h / Inert atmosphere; Reflux; Dean-Stark
2.1: copper(l) chloride; 1,3-dimethyl-2-imidazolidinone; lithium hexamethyldisilazane; chloro-trimethyl-silane / tetrahydrofuran / 0.5 h / -60 - 10 °C / Inert atmosphere
2.2: 3.67 h / 5 - 25 °C
With
1,3-dimethyl-2-imidazolidinone; chloro-trimethyl-silane; methanesulfonic acid; copper(l) chloride; lithium hexamethyldisilazane;
In
tetrahydrofuran; diethylene glycol dimethyl ether; toluene;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: methanesulfonic acid / diethylene glycol dimethyl ether; toluene / 14.5 h / Inert atmosphere; Reflux; Dean-Stark
2.1: copper(l) chloride; 1,3-dimethyl-2-imidazolidinone; lithium hexamethyldisilazane; chloro-trimethyl-silane / tetrahydrofuran / 0.5 h / -60 - 10 °C / Inert atmosphere
2.2: 3.67 h / 5 - 25 °C
With
1,3-dimethyl-2-imidazolidinone; chloro-trimethyl-silane; methanesulfonic acid; copper(l) chloride; lithium hexamethyldisilazane;
In
tetrahydrofuran; diethylene glycol dimethyl ether; toluene;