methyl 3,3-dibutyl-7-(methyloxy)-5-phenyl-2,3-dihydro-1,4-benzothiazepine-8-carboxylate

Base Information

Chemical Name:methyl 3,3-dibutyl-7-(methyloxy)-5-phenyl-2,3-dihydro-1,4-benzothiazepine-8-carboxylate
CAS No.:1345983-72-3
Molecular Formula:C₂₆H₃₃NO₃S
Molecular Weight:439.619
Hs Code.:

Synonyms:methyl 3,3-dibutyl-7-(methyloxy)-5-phenyl-2,3-dihydro-1,4-benzothiazepine-8-carboxylate

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Chemical Property of methyl 3,3-dibutyl-7-(methyloxy)-5-phenyl-2,3-dihydro-1,4-benzothiazepine-8-carboxylate

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Technology Process of methyl 3,3-dibutyl-7-(methyloxy)-5-phenyl-2,3-dihydro-1,4-benzothiazepine-8-carboxylate

There total 14 articles about methyl 3,3-dibutyl-7-(methyloxy)-5-phenyl-2,3-dihydro-1,4-benzothiazepine-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 67-56-1
methanol

: 201230-82-2
carbon monoxide

: 1345983-71-2
8-bromo-3,3-dibutyl-7-(methyloxy)-5-phenyl-2,3-dihydro-1,4-benzothiazepine

: 1345983-72-3
methyl 3,3-dibutyl-7-(methyloxy)-5-phenyl-2,3-dihydro-1,4-benzothiazepine-8-carboxylate

Guidance literature:: With 1,3-bis-(diphenylphosphino)propane; triethylamine; palladium diacetate; In dimethyl sulfoxide; at 70 ℃; for 42h;

Reference yield:

: 616-06-8
2-amino-hexanoic acid

: 1345983-72-3
methyl 3,3-dibutyl-7-(methyloxy)-5-phenyl-2,3-dihydro-1,4-benzothiazepine-8-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: thionyl chloride / 0 - 65 °C

2.1: magnesium sulfate; triethylamine / dichloromethane / 2 h / 25 °C

2.2: 0.5 h

2.3: 60 h / 25 °C

3.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 - 25 °C

3.2: 20 h / 25 °C

4.1: hydrogenchloride; water / 0.5 h / 25 °C

4.2: 0 °C / pH 12

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 - 65 °C

5.2: 2 h / 0 °C

6.1: chlorosulfonic acid / ethyl acetate / 3 h / 25 - 40 °C

7.1: potassium hydroxide / ethanol; water / 18 h / 70 °C / Reflux

7.2: 15 h / 85 °C

8.1: citric acid / toluene / 50 h / 130 °C / Reflux

9.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / dimethyl sulfoxide / 42 h / 70 °C

With hydrogenchloride; chlorosulfonic acid; lithium aluminium tetrahydride; thionyl chloride; 1,3-bis-(diphenylphosphino)propane; water; sodium hydride; magnesium sulfate; triethylamine; citric acid; potassium hydroxide; palladium diacetate; In tetrahydrofuran; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 393855-85-1
2-amino-2-butylhexanyl hydrogen sulfate

: 1345983-72-3
methyl 3,3-dibutyl-7-(methyloxy)-5-phenyl-2,3-dihydro-1,4-benzothiazepine-8-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium hydroxide / ethanol; water / 18 h / 70 °C / Reflux

1.2: 15 h / 85 °C

2.1: citric acid / toluene / 50 h / 130 °C / Reflux

3.1: triethylamine; 1,3-bis-(diphenylphosphino)propane / palladium diacetate / dimethyl sulfoxide / 42 h / 70 °C

With 1,3-bis-(diphenylphosphino)propane; triethylamine; citric acid; potassium hydroxide; palladium diacetate; In ethanol; water; dimethyl sulfoxide; toluene;