2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-yl)acetamidine acetic acid salt

Base Information

Chemical Name:2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-yl)acetamidine acetic acid salt
CAS No.:1616924-46-9
Molecular Formula:C₂H₄O₂*C₁₆H₂₂N₂O₂
Molecular Weight:334.415
Hs Code.:

Synonyms:2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-yl)acetamidine acetic acid salt

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Chemical Property of 2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-yl)acetamidine acetic acid salt

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Technology Process of 2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-yl)acetamidine acetic acid salt

There total 6 articles about 2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-yl)acetamidine acetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.79%

: 1616924-44-7
(Z)-(1-amino-2-{8-phenyl-1,4-dioxaspiro[4.5]decan-8-yl}ethylidene)amino acetate

: 1616924-46-9
2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-yl)acetamidine acetic acid salt

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 60356-11-8
cyano(1,4-dioxaspiro[4.5]dec-8-ylidene)acetic acid ethyl ester

: 1616924-46-9
2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-yl)acetamidine acetic acid salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: copper(l) iodide / tetrahydrofuran; dibutyl ether / 2 h / -78 - -30 °C

1.2: 1 h / -78 - -30 °C

2.1: sodium iodide / dimethyl sulfoxide / 3 h / 150 °C / Sealed tube

2.2: 16 h / 20 °C

3.1: hydroxylamine / ethanol; water / 16 h / 60 °C

4.1: 16 h / 20 °C

5.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C / Inert atmosphere

With copper(l) iodide; palladium 10% on activated carbon; hydrogen; hydroxylamine; sodium iodide; In tetrahydrofuran; methanol; ethanol; dibutyl ether; water; dimethyl sulfoxide;

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 1616924-46-9
2-(8-phenyl-1,4-dioxaspiro[4.5]dec-8-yl)acetamidine acetic acid salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid; ammonium acetate / toluene / 16 h / Dean-Stark; Reflux

2.1: copper(l) iodide / tetrahydrofuran; dibutyl ether / 2 h / -78 - -30 °C

2.2: 1 h / -78 - -30 °C

3.1: sodium iodide / dimethyl sulfoxide / 3 h / 150 °C / Sealed tube

3.2: 16 h / 20 °C

4.1: hydroxylamine / ethanol; water / 16 h / 60 °C

5.1: 16 h / 20 °C

6.1: hydrogen; palladium 10% on activated carbon / methanol / 2 h / 20 °C / Inert atmosphere

With copper(l) iodide; palladium 10% on activated carbon; ammonium acetate; hydrogen; hydroxylamine; acetic acid; sodium iodide; In tetrahydrofuran; methanol; ethanol; dibutyl ether; water; dimethyl sulfoxide; toluene;