Nitric Oxide

Base Information

• Chemical Name: Nitric Oxide
• CAS No.: 10102-43-9
• Deprecated CAS: 51005-20-0,51005-21-1,90452-29-2
• Molecular Formula: NO
• Molecular Weight: 32.022
• European Community (EC) Number: 233-271-0
• ICSC Number: 1311
• UN Number: 1660
• UNII: 31C4KY9ESH
• DSSTox Substance ID: DTXSID1020938
• Nikkaji Number: J1.313.254B,J415.432K
• Wikipedia: Nitric oxide,Nitrogen monoxide,Nitric_oxide
• NCI Thesaurus Code: C695
• RXCUI: 7442
• Pharos Ligand ID: nitric oxide
• ChEMBL ID: CHEMBL1200689
• Mol file: 10102-43-9.mol

Synonyms:Endogenous Nitrate Vasodilator;Endothelium-Derived Nitric Oxide;Mononitrogen Monoxide;Monoxide, Mononitrogen;Monoxide, Nitrogen;Nitrate Vasodilator, Endogenous;Nitric Oxide;Nitric Oxide, Endothelium Derived;Nitric Oxide, Endothelium-Derived;Nitrogen Monoxide;Oxide, Nitric;Vasodilator, Endogenous Nitrate

Chemical Property of Nitric Oxide

Chemical Property:

• Appearance/Colour: colourless gas turning brown upon exposure to air
• Melting Point: -163.6 °C(lit.)
• Boiling Point: -151.7 °C(lit.)
• PSA: 17.07000
• Density: 1.24 g/cmsup>3</sup>
• LogP: -0.44710
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 29.997988624
• Heavy Atom Count: 2
• Complexity: 2
• Transport DOT Label: Poison Gas Oxidizer Corrosive

Purity/Quality:

99.9% ^*data from raw suppliers

Safty Information:

• Pictogram(s): O, T
• Hazard Codes: O, T

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Toxic Gases & Vapors -> Oxidizers
• Canonical SMILES: [N]=O
• Recent ClinicalTrials: Nitric Oxide During Bypass for Arterial Switch Operation
• Recent EU Clinical Trials: Role of inhaled nitric oxide on right ventricular function and pulmonary vascular mechanics following cardiac surgery
• Recent NIPH Clinical Trials: RIPC improves diabetic control for 15 weeks in type 2 diabetes
• Inhalation Risk: A harmful concentration of this gas in the air will be reached very quickly on loss of containment.
• Effects of Short Term Exposure: Inhalation of high concentrations of the gas may cause damage to the lungs.
• Effects of Long Term Exposure: Repeated or prolonged inhalation may cause effects on the lungs.

Technology Process of Nitric Oxide

There total 1439 articles about Nitric Oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ascorbic acid (50-81-7,98966-42-8) + sodium nitrite (7632-00-0) → water (7732-18-5) + nitrogen(II) oxide (10102-43-9) + Nitrogen dioxide (10102-44-0) + sodium L-ascorbate (146-75-8,6381-77-7,6866-66-6,7317-67-1,7378-23-6,21547-69-3,58657-35-5,134-03-2)

Guidance literature:

Product distribution / selectivity;

Reference yield:

ascorbic acid (50-81-7,98966-42-8) + sodium nitrite (7632-00-0) → nitrogen(II) oxide (10102-43-9) + sodium L-ascorbate (146-75-8,6381-77-7,6866-66-6,7317-67-1,7378-23-6,21547-69-3,58657-35-5,134-03-2)

Guidance literature:

Reference yield:

formic acid (64-18-6) + nitric acid (7697-37-2,78989-43-2) → carbon dioxide (124-38-9,18923-20-1) + nitrogen(II) oxide (10102-43-9) + Nitrogen dioxide (10102-44-0) + dinitrogen monoxide (10024-97-2)

Guidance literature:

In nitric acid; 323 K, glass reactor, 3 N HNO3, 1 N HCOOH; Kinetics;

DOI:10.1246/cl.2004.418

upstream raw materials:

2-iodo-propane

tert.-butylnitrite

methyl nitrite

i-propyl nitrite

Downstream raw materials:

nitrogen

methyl 2-nitroacetate

1,3-dihydroisobenzofuran-1-ol

o-phthalic dicarboxaldehyde

Refernces

• 1、 Holanda, Alda K.M.,da Silva, Francisco O.N.,Sousa, Jackson R.,Diógenes, Izaura C.N.,Carvalho, Idalina M.M.,Moreira, ícaro S.,Clarke, Michael J.,Lopes, Luiz G.F.. "Photochemical NO release from nitrosyl RuII complexes with C-bound imidazoles". . p. 2929 - 2933. Retrieved 2008.
• 2、 Hsu, D. S. Y.,Squire, D. W.,Lin, M. C.. "The rotational energy accommodation of NO formed in the catalytic oxidation of NH3 over Pt(111)". . p. 2861 - 2865. Retrieved 1988.
• 3、 Jayabal, Subramaniam,Viswanathan, Perumal,Ramaraj, Ramasamy. "Reduced graphene oxide-gold nanorod composite material stabilized in silicate sol-gel matrix for nitric oxide sensor". . p. 33541 - 33548. Retrieved 2014.
• 4、 McGivern, W. Sean,North, Simon W.. "Probing the nature of the K-rotor in unimolecular reactions: Scalar and vector correlations in the photodissociation of NCNO". . p. 7027 - 7034. Retrieved 2002.
• 5、 Oktar, Nuray,Mitome, Junko,Holmgreen, Erik M.,Ozkan, Umit S.. "Catalytic reduction of N2O and NO2 with methane over sol-gel palladium-based catalysts". . p. 171 - 182. Retrieved 2006.
• 6、 Kozub, Galina I.,Sanina, Nataliya A.,Emel'yanova, Nina S.,Utenishev, Andrey N.,Kondrat'eva, Tat'yana A.,Khrustalev, Vladimir N.,Ovanesyan, Nikolay S.,Kupchinskaya, Nadezhda E.,Aldoshin, Sergey M.. "[Fe2(μ-SR)2(NO)4]0 complexes with R being phenolyl with different substituents in the meta-position: Synthesis, structure, and NO release". . p. 132 - 139. Retrieved 2018.
• 7、 Cacita, Natacha,Possato, Bruna,Da Silva, Camila F.N.,Paulo, Michele,Formiga, André Luiz Barbosa,Bendhack, Lusiane M.,Nikolaou, Sofia. "Investigation of a novel trinuclear μ-oxo ruthenium complex as a potential nitric oxide releaser for biological purposes". . p. 114 - 121. Retrieved 2015.
• 8、 McQuaid, Michael J.,Miziolek, Andrzej W.,Sausa, Rosario C.,Merrow, Clifton N.. "Photodissociation of Dimethylnitramine at 248 nm". . p. 2713 - 2718. Retrieved 1991.
• 9、 Olbert-Majkuta, Adriana,Mielke, Zofia,Tokhadze, Konstantin G.. "Photolysis of the C2H4-HONO complex in low temperature matrices: Formation of 2-nitrosoethanol". . p. 321 - 332. Retrieved 2003.
• 10、 Veyret, B.,Lesclaux, R.. "Absolute Rate Constants for the Reactions of HCO with O2 and NO from 298 to 503 K". . p. 1918 - 1922. Retrieved 1981.