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Basic Information

Molecular Structure:
CAS No.:	7632-00-0
Name:	Sodium nitrite
Article Data:	189

Formula:	NaNO₂
Molecular Weight:	68.9953
Synonyms:	Natrium nitrit;Nitrous acid sodium salt;Dusitan sodny;Anti-Rust;Nitrite de sodium;Diazotizing salts;Erinitrit;NCI-C02084;Filmerine;Synfat 1004;Nitrous acid, sodium salt;M 138C;Sodium Nitrite for Industrial use;Industrial Sodium Nitrite;
EINECS:	231-555-9
Density:	2.168 g/cm³
Melting Point:	271 °C(lit.)
Boiling Point:	320 °C
Solubility:	820 g/L (20 °C) in water
Appearance:	white to off-white powder
Hazard Symbols:	O, T, N, Xn
Risk Codes:	8-25-50-22-36/38
Safety:	45-61-36-26
Transport Information:	UN 3219 5.1/PG 3
PSA:	52.49000
LogP:	0.25060

Synthetic route

...Expand

: 7631-99-4
sodium nitrate

: 7632-00-0
sodium nitrite

: 1493-05-6
difluoro-nitro-methane

: 141-52-6
sodium ethanolate

A: sodium fluoride

B: 7632-00-0
sodium nitrite

C: 105-58-8
Diethyl carbonate

Conditions

Conditions	Yield
In ethanol; dichloromethane alkoxide soln. (EtOH) addn. to F2C(NO2)2 soln. (CH2Cl2) (molar ratio F2C(NO2)2:nucleophile=1:4), reacting (-10°C for 10-15 min), stirring (0°C for 1 h, then 20°C for 1 h); salts. ppt. sepn. (CH2Cl2 addn.); chem. and GLC anal.;	A 81% B 78% C 7%
In ethanol; dichloromethane alkoxide soln. (EtOH) addn. to F2C(NO2)2 soln. (CH2Cl2) (molar ratio F2C(NO2)2:nucleophile 1:2, reacting (-10°C for 10-15 min), stirring(0°C for 1 h), reaction mixt. leaving overnight at -20°C; salts. ppt. sepn. (CH2Cl2 addn., cooling), ppt. treatment with boiling ethanol, NaNO2 pptn. from filtrate, aq. H2SO4 addn. to filtrate, org. layer sepn., aq. layer extn. (CH2Cl2), ext. drying (MgSO4), distn. lead to(EtO)2CO; chem. and GLC anal.;	A 48% B 62% C 12%
In ethanol; dichloromethane alkoxide soln. (EtOH) addn. to F2C(NO2)2 soln. (CH2Cl2) (molar ratio F2C(NO2)2:nucleophile=1:1), reacting (-10°C for 10-15 min), stirring (0°C for 1 h, then 20°C for 1 h); salts. ppt. sepn. (CH2Cl2 addn.); chem. and GLC anal.;	A 18% B 26% C 9%
In ethanol; N,N-dimethyl-formamide alkoxide soln. (EtOH) addn. to F2C(NO2)2 soln. (DMF) (molar ratio F2C(NO2)2:nucleophile=1:2), reacting (-10°C for 10-15 min), stirring (0°C for 1 h); salts. ppt. sepn. (CH2Cl2 addn.); chem. and GLC anal.;

...Expand

: sodium sulfide

: 13477-34-4
calcium(II) nitrate

: 7757-83-7
sodium sulfite

A: calcium sulfate

B: 7757-82-6
sodium sulfate

C: 7632-00-0
sodium nitrite

Conditions

Conditions	Yield
In neat (no solvent) formation at heating under glowing;;	A n/a B n/a C 60%

...Expand

: 1493-05-6
difluoro-nitro-methane

: 141-52-6
sodium ethanolate

A: 3812-32-6
carbonate(2-)

B: sodium fluoride

C: 7632-00-0
sodium nitrite

D: 105-58-8
Diethyl carbonate

Conditions

Conditions	Yield
In ethanol byproducts: NO3(1-); alkoxide soln. addn. to F2C(NO2)2 soln. (molar ratio F2C(NO2)2:nucleophile=1:2), reacting (-10°C for 10-15 min), stirring (0°C for 1 h, then 20°C for 1 h); salts. ppt. sepn. (CH2Cl2 addn.); chem. and GLC anal.;	A 8% B 43% C n/a D 14%

...Expand

: 21824-10-2
fluorotrinitromethane

: 141-52-6
sodium ethanolate

A: 17021-83-9
ethoxyfluorodinitromethane

B: sodium fluoride

C: 7632-00-0
sodium nitrite

D: 105-58-8
Diethyl carbonate

Conditions

Conditions	Yield
In ethanol; dichloromethane alkoxide soln. (EtOH) addn. (dropwise) to FC(NO2)3 soln. (CH2Cl2) (molar ratio FC(NO2)3:nucleophile=1:2), stirring (0-5°C for 1.5 h), 5%H2SO4 soln. addn., extn. (CH2Cl2), drying (MgSO4); residue distn. (vac.), ppt. sepn.; chem. and GLC anal., IR spectroscopy;	A 42% B n/a C n/a D 6.8%

...Expand

: 96088-55-0
N,N-bis(methylsulfonyl)hydroxylamine

A: 20277-69-4
sodium methansulfinate

B: 7632-00-0
sodium nitrite

Conditions

Conditions	Yield
With sodium hydroxide In water Product distribution; Mechanism; hydrolysis with basic, neutral and acidic aqu. solutions, also in addition of NaN3 (other products);

: 1310-73-2
sodium hydroxide

: 10102-44-0
Nitrogen dioxide

: 7632-00-0
sodium nitrite

: sodium peroxide

: 16824-89-8, 12533-50-5
N-oxo-N-nitrosoamine

: 7632-00-0
sodium nitrite

Conditions

Conditions	Yield
In neat (no solvent) at 150°C;;

: sodium hyponitrite

: 10102-44-0
Nitrogen dioxide

A: 7631-99-4
sodium nitrate

B: 7632-00-0
sodium nitrite

Conditions

Conditions	Yield
oxidation;
oxidation;

...Expand

Raw Materials

144-55-8

Downstream Products

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Consensus Reports

Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.

Standards and Recommendations

DOT Classification: 5.1; Label: Oxidizer

Specification

Sodium Nitrite, its cas register number is 7632-00-0. It also can be called Anti-rust; Azotyn sodowy; Diazotizing salts;Dusitan sodny; Erinitrit; Filmerine; Natrium nitrit; Nitrite de sodium; Nitrito sodico. Sodium nitrite is the inorganic compound with the chemical formula NaNO₂. It is a white to slight yellowish crystalline powder that is very soluble in water and is hygroscopic.It is a Nitrous acid sodium salt. And it is used in many industrial processes, in meat curing, coloring, and preserving, and as a reagent in analytical chemistry techniques. It is used therapeutically as an antidote in cyanide poisoning. The compound is toxic and mutagenic and will react in vivo with secondary or tertiary amines thereby producing highly carcinogenic nitrosamines.

Preparation of Sodium Nitrite:
Sodium Nitrite is prepared by treating sodium hydroxide with mixtures of nitrogen dioxide and nitric oxide:
2 NaOH + NO₂ + NO → 2 NaNO₂ + H₂O
The conversion is sensitive to the presence of oxygen, which can lead to varying amounts of sodium nitrate.
In former times, sodium nitrite was prepared by reduction of sodium nitrate with various metals.

Uses of Sodium Nitrite:
Sodium nitrite (NaNO₂) is a chemical compound commonly used in fertilizers, food preservatives, smoke bombs, as a color fixative, dyes and pyrotechnics.The main use of sodium nitrite is for the industrial production of organonitrogen compounds. It is a reagent for conversion of amines into diazo compounds.Sodium nitrite can be used as part of an intravenous mixture to treat cyanide poisoning.It is well known for its role in inhibiting the growth of Clostridium botulinum spores in refrigerated meats.

Safety information of Sodium Nitrite:
When you are using Sodium Nitrite, please be cautious about it as the following:(1)In case of accident or if you feel unwell, seek medical advice immediately (show label where possible); (2)Avoid release to the environment. Refer to special instructions safety data sheet; (3)Wear suitable protective clothing; (4)In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;

You can still convert the following datas into molecular structure:
(1)InChI=1S/HNO2.Na/c2-1-3;/h(H,2,3);/q;+1/p-1;
(2)InChIKey=LPXPTNMVRIOKMN-UHFFFAOYSA-M;
(3)SmilesN(=O)[O-].[Na+];

The toxicity data of Sodium Nitrite is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	oral	1500mg/kg (1500mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1372, 1935.
cat	LDLo	subcutaneous	35mg/kg (35mg/kg)	GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: CYANOSIS LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 126, Pg. 209, 1927.
chicken	LD50	oral	28944ug/kg (28.944mg/kg)		American Journal of Veterinary Research. Vol. 30, Pg. 2185, 1969.
child	LDLo	oral	22mg/kg (22mg/kg)	VASCULAR: OTHER CHANGES	Lancet. Vol. 2, Pg. 162, 1917.
dog	LDLo	intravenous	15mg/kg (15mg/kg)		"Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 245, 1973.
dog	LDLo	oral	330mg/kg (330mg/kg)		"Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 245, 1973.
dog	LDLo	subcutaneous	60mg/kg (60mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) GASTROINTESTINAL: NAUSEA OR VOMITING	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 21, Pg. 425, 1911.
frog	LDLo	subcutaneous	1gm/kg (1000mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1372, 1935.
human	LDLo	oral	71mg/kg (71mg/kg)	BEHAVIORAL: COMA BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN GASTROINTESTINAL: NAUSEA OR VOMITING	"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 543, 1969.
human	TDLo	oral	14mg/kg (14mg/kg)	GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION	Deutsche Medizinische Wochenschrift. Vol. 74, Pg. 961, 1949.
man	LDLo	oral	321mg/kg (321mg/kg)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: CYANOSIS BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN	Israel Journal of Medical Sciences. Vol. 28, Pg. 289, 1992.
man	TDLo	oral	1714ug/kg/70M (1.714mg/kg)	CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	Journal of Clinical Investigation. Vol. 16, Pg. 73, 1937.
mouse	LD50	intraperitoneal	158mg/kg (158mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 165, Pg. 30, 1969.
mouse	LD50	oral	175mg/kg (175mg/kg)	VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION	FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 97, 1974.
mouse	LDLo	subcutaneous	150mg/kg (150mg/kg)	BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: NAUSEA OR VOMITING	Archives Internationales de Pharmacodynamie et de Therapie. Vol. 35, Pg. 480, 1929.
rabbit	LD50	oral	186mg/kg (186mg/kg)		Southwestern Veterinarian. Vol. 27, Pg. 246, 1974.
rabbit	LDLo	intravenous	80mg/kg (80mg/kg)	PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: COMA KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED	Journal of Pharmacology and Experimental Therapeutics. Vol. 41, Pg. 121, 1931.
rabbit	LDLo	subcutaneous	60mg/kg (60mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1372, 1935.
rat	LC50	inhalation	5500ug/m3/4H (5.5mg/m3)		Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 16(10), Pg. 36, 1972.
rat	LD50	intravenous	65mg/kg (65mg/kg)		Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 320, 1963.
rat	LD50	oral	180mg/kg (180mg/kg)		American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969.
rat	LD50	subcutaneous	96600ug/kg (96.6mg/kg)		Archives of Toxicology, Supplement. Vol. 14, Pg. 231, 1991.