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| CAS No.: | 7632-00-0 |
|---|---|
| Name: | Sodium nitrite |
| Article Data: | 189 |
| Molecular Structure: | |
|
|
|
| Formula: | NaNO2 |
| Molecular Weight: | 68.9953 |
| Synonyms: | Natrium nitrit;Nitrous acid sodium salt;Dusitan sodny;Anti-Rust;Nitrite de sodium;Diazotizing salts;Erinitrit;NCI-C02084;Filmerine;Synfat 1004;Nitrous acid, sodium salt;M 138C;Sodium Nitrite for Industrial use;Industrial Sodium Nitrite; |
| EINECS: | 231-555-9 |
| Density: | 2.168 g/cm3 |
| Melting Point: | 271 °C(lit.) |
| Boiling Point: | 320 °C |
| Solubility: | 820 g/L (20 °C) in water |
| Appearance: | white to off-white powder |
| Hazard Symbols: |
 O,  T,  N,  Xn
|
| Risk Codes: | 8-25-50-22-36/38 |
| Safety: | 45-61-36-26 |
| Transport Information: | UN 3219 5.1/PG 3 |
| PSA: | 52.49000 |
| LogP: | 0.25060 |
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- 1493-05-6
difluoro-nitro-methane
- 141-52-6
sodium ethanolate
B
- 7632-00-0
sodium nitrite
C
- 105-58-8
Diethyl carbonate
| Conditions | Yield |
|---|---|
| In ethanol; dichloromethane alkoxide soln. (EtOH) addn. to F2C(NO2)2 soln. (CH2Cl2) (molar ratio F2C(NO2)2:nucleophile=1:4), reacting (-10°C for 10-15 min), stirring (0°C for 1 h, then 20°C for 1 h); salts. ppt. sepn. (CH2Cl2 addn.); chem. and GLC anal.; | A 81% B 78% C 7% |
| In ethanol; dichloromethane alkoxide soln. (EtOH) addn. to F2C(NO2)2 soln. (CH2Cl2) (molar ratio F2C(NO2)2:nucleophile 1:2, reacting (-10°C for 10-15 min), stirring(0°C for 1 h), reaction mixt. leaving overnight at -20°C; salts. ppt. sepn. (CH2Cl2 addn., cooling), ppt. treatment with boiling ethanol, NaNO2 pptn. from filtrate, aq. H2SO4 addn. to filtrate, org. layer sepn., aq. layer extn. (CH2Cl2), ext. drying (MgSO4), distn. lead to(EtO)2CO; chem. and GLC anal.; | A 48% B 62% C 12% |
| In ethanol; dichloromethane alkoxide soln. (EtOH) addn. to F2C(NO2)2 soln. (CH2Cl2) (molar ratio F2C(NO2)2:nucleophile=1:1), reacting (-10°C for 10-15 min), stirring (0°C for 1 h, then 20°C for 1 h); salts. ppt. sepn. (CH2Cl2 addn.); chem. and GLC anal.; | A 18% B 26% C 9% |
| In ethanol; N,N-dimethyl-formamide alkoxide soln. (EtOH) addn. to F2C(NO2)2 soln. (DMF) (molar ratio F2C(NO2)2:nucleophile=1:2), reacting (-10°C for 10-15 min), stirring (0°C for 1 h); salts. ppt. sepn. (CH2Cl2 addn.); chem. and GLC anal.; |
- 13477-34-4
calcium(II) nitrate
- 7757-83-7
sodium sulfite
B
- 7757-82-6
sodium sulfate
C
- 7632-00-0
sodium nitrite
| Conditions | Yield |
|---|---|
| In neat (no solvent) formation at heating under glowing;; | A n/a B n/a C 60% |
- 1493-05-6
difluoro-nitro-methane
- 141-52-6
sodium ethanolate
A
- 3812-32-6
carbonate(2-)
C
- 7632-00-0
sodium nitrite
D
- 105-58-8
Diethyl carbonate
| Conditions | Yield |
|---|---|
| In ethanol byproducts: NO3(1-); alkoxide soln. addn. to F2C(NO2)2 soln. (molar ratio F2C(NO2)2:nucleophile=1:2), reacting (-10°C for 10-15 min), stirring (0°C for 1 h, then 20°C for 1 h); salts. ppt. sepn. (CH2Cl2 addn.); chem. and GLC anal.; | A 8% B 43% C n/a D 14% |
- 21824-10-2
fluorotrinitromethane
- 141-52-6
sodium ethanolate
A
- 17021-83-9
ethoxyfluorodinitromethane
C
- 7632-00-0
sodium nitrite
D
- 105-58-8
Diethyl carbonate
| Conditions | Yield |
|---|---|
| In ethanol; dichloromethane alkoxide soln. (EtOH) addn. (dropwise) to FC(NO2)3 soln. (CH2Cl2) (molar ratio FC(NO2)3:nucleophile=1:2), stirring (0-5°C for 1.5 h), 5%H2SO4 soln. addn., extn. (CH2Cl2), drying (MgSO4); residue distn. (vac.), ppt. sepn.; chem. and GLC anal., IR spectroscopy; | A 42% B n/a C n/a D 6.8% |
- 96088-55-0
N,N-bis(methylsulfonyl)hydroxylamine
A
- 20277-69-4
sodium methansulfinate
B
- 7632-00-0
sodium nitrite
| Conditions | Yield |
|---|---|
| With sodium hydroxide In water Product distribution; Mechanism; hydrolysis with basic, neutral and acidic aqu. solutions, also in addition of NaN3 (other products); |
| Conditions | Yield |
|---|---|
| In neat (no solvent) at 150°C;; |
| Conditions | Yield |
|---|---|
| oxidation; | |
| oxidation; |
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Consensus Reports
Reported in EPA TSCA Inventory. EPA Genetic Toxicology Program.
Standards and Recommendations
DOT Classification: 5.1; Label: Oxidizer
Specification
Sodium Nitrite, its cas register number is 7632-00-0. It also can be called Anti-rust; Azotyn sodowy; Diazotizing salts;Dusitan sodny; Erinitrit; Filmerine; Natrium nitrit; Nitrite de sodium; Nitrito sodico. Sodium nitrite is the inorganic compound with the chemical formula NaNO2. It is a white to slight yellowish crystalline powder that is very soluble in water and is hygroscopic.It is a Nitrous acid sodium salt. And it is used in many industrial processes, in meat curing, coloring, and preserving, and as a reagent in analytical chemistry techniques. It is used therapeutically as an antidote in cyanide poisoning. The compound is toxic and mutagenic and will react in vivo with secondary or tertiary amines thereby producing highly carcinogenic nitrosamines.
Preparation of Sodium Nitrite:
Sodium Nitrite is prepared by treating sodium hydroxide with mixtures of nitrogen dioxide and nitric oxide:
2 NaOH + NO2 + NO → 2 NaNO2 + H2O
The conversion is sensitive to the presence of oxygen, which can lead to varying amounts of sodium nitrate.
In former times, sodium nitrite was prepared by reduction of sodium nitrate with various metals.
Uses of Sodium Nitrite:
Sodium nitrite (NaNO2) is a chemical compound commonly used in fertilizers, food preservatives, smoke bombs, as a color fixative, dyes and pyrotechnics.The main use of sodium nitrite is for the industrial production of organonitrogen compounds. It is a reagent for conversion of amines into diazo compounds.Sodium nitrite can be used as part of an intravenous mixture to treat cyanide poisoning.It is well known for its role in inhibiting the growth of Clostridium botulinum spores in refrigerated meats.
Safety information of Sodium Nitrite:
When you are using Sodium Nitrite, please be cautious about it as the following:(1)In case of accident or if you feel unwell, seek medical advice immediately (show label where possible); (2)Avoid release to the environment. Refer to special instructions safety data sheet; (3)Wear suitable protective clothing; (4)In case of contact with eyes, rinse immediately with plenty of water and seek medical advice;
You can still convert the following datas into molecular structure:
(1)InChI=1S/HNO2.Na/c2-1-3;/h(H,2,3);/q;+1/p-1;
(2)InChIKey=LPXPTNMVRIOKMN-UHFFFAOYSA-M;
(3)SmilesN(=O)[O-].[Na+];
The toxicity data of Sodium Nitrite is as follows:
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| cat | LDLo | oral | 1500mg/kg (1500mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1372, 1935. | |
| cat | LDLo | subcutaneous | 35mg/kg (35mg/kg) | GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: CYANOSIS LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. Vol. 126, Pg. 209, 1927. |
| chicken | LD50 | oral | 28944ug/kg (28.944mg/kg) | American Journal of Veterinary Research. Vol. 30, Pg. 2185, 1969. | |
| child | LDLo | oral | 22mg/kg (22mg/kg) | VASCULAR: OTHER CHANGES | Lancet. Vol. 2, Pg. 162, 1917. |
| dog | LDLo | intravenous | 15mg/kg (15mg/kg) | "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 245, 1973. | |
| dog | LDLo | oral | 330mg/kg (330mg/kg) | "Drug Dosages in Laboratory Animals - A Handbook," Rev. ed., Barnes, C.D., and L.G. Eltherington, Berkeley, Univ. of California Press, 1973Vol. -, Pg. 245, 1973. | |
| dog | LDLo | subcutaneous | 60mg/kg (60mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD PERIPHERAL NERVE AND SENSATION: FLACCID PARALYSIS WITHOUT ANESTHESIA (USUALLY NEUROMUSCULAR BLOCKAGE) GASTROINTESTINAL: NAUSEA OR VOMITING | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 21, Pg. 425, 1911. |
| frog | LDLo | subcutaneous | 1gm/kg (1000mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1372, 1935. | |
| human | LDLo | oral | 71mg/kg (71mg/kg) | BEHAVIORAL: COMA BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN GASTROINTESTINAL: NAUSEA OR VOMITING | "Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 543, 1969. |
| human | TDLo | oral | 14mg/kg (14mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION | Deutsche Medizinische Wochenschrift. Vol. 74, Pg. 961, 1949. |
| man | LDLo | oral | 321mg/kg (321mg/kg) | BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: CYANOSIS BLOOD: METHEMOGLOBINEMIA-CARBOXYHEMOGLOBIN | Israel Journal of Medical Sciences. Vol. 28, Pg. 289, 1992. |
| man | TDLo | oral | 1714ug/kg/70M (1.714mg/kg) | CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | Journal of Clinical Investigation. Vol. 16, Pg. 73, 1937. |
| mouse | LD50 | intraperitoneal | 158mg/kg (158mg/kg) | Journal of Pharmacology and Experimental Therapeutics. Vol. 165, Pg. 30, 1969. | |
| mouse | LD50 | oral | 175mg/kg (175mg/kg) | VASCULAR: REGIONAL OR GENERAL ARTERIOLAR OR VENOUS DILATION VASCULAR: BP LOWERING NOT CHARACTERIZED IN AUTONOMIC SECTION | FAO Nutrition Meetings Report Series. Vol. 53A, Pg. 97, 1974. |
| mouse | LDLo | subcutaneous | 150mg/kg (150mg/kg) | BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: NAUSEA OR VOMITING | Archives Internationales de Pharmacodynamie et de Therapie. Vol. 35, Pg. 480, 1929. |
| rabbit | LD50 | oral | 186mg/kg (186mg/kg) | Southwestern Veterinarian. Vol. 27, Pg. 246, 1974. | |
| rabbit | LDLo | intravenous | 80mg/kg (80mg/kg) | PERIPHERAL NERVE AND SENSATION: SPASTIC PARALYSIS WITH OR WITHOUT SENSORY CHANGE BEHAVIORAL: COMA KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED | Journal of Pharmacology and Experimental Therapeutics. Vol. 41, Pg. 121, 1931. |
| rabbit | LDLo | subcutaneous | 60mg/kg (60mg/kg) | "Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1372, 1935. | |
| rat | LC50 | inhalation | 5500ug/m3/4H (5.5mg/m3) | Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 16(10), Pg. 36, 1972. | |
| rat | LD50 | intravenous | 65mg/kg (65mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 13, Pg. 320, 1963. | |
| rat | LD50 | oral | 180mg/kg (180mg/kg) | American Industrial Hygiene Association Journal. Vol. 30, Pg. 470, 1969. | |
| rat | LD50 | subcutaneous | 96600ug/kg (96.6mg/kg) | Archives of Toxicology, Supplement. Vol. 14, Pg. 231, 1991. |