Dioxypyramidon

Base Information

• Chemical Name: Dioxypyramidon
• CAS No.: 519-65-3
• Molecular Formula: C13H17 N3 O3
• Molecular Weight: 263.296
• Hs Code.: 2928000090
• European Community (EC) Number: 208-274-5
• UNII: DU4PCE8X72
• DSSTox Substance ID: DTXSID00199862
• Nikkaji Number: J182.279I
• Wikidata: Q27156925
• Mol file: 519-65-3.mol

Synonyms:Dioxypyramidon;Dioxoaminopyrine;519-65-3;Dioxyaminopyrine;N'-Acetyl-2-(dimethylamino)-N'-methyl-2-oxo-N-phenylacetohydrazide;AMDOPH;EINECS 208-274-5;2-(N-[acetyl(methyl)amino]anilino)-N,N-dimethyl-2-oxoacetamide;UNII-DU4PCE8X72;BRN 1822610;DU4PCE8X72;Semioxamazide, 1-acetyl-2-phenyl-1,5,5-trimethyl-;4-15-00-00173 (Beilstein Handbook Reference);C13H17N3O3;Acetic acid, (dimethylamino)oxo-, 2-acetyl-2-methyl-1-phenylhydrazide;DIOXYPYRAMIDON [MI];DIOXYPYRAMIDON [WHO-DD];CHEBI:83534;DTXSID00199862;LS-144911;FT-0667629;1-acetyl-1-methyl-2-dimethyloxamoyl-2-phenylhydrazine;Q27156925;1-Acetyl-1-methyl-2-(dimethyloxamoyl)-2-phenylhydrazine;1-(N'-acetyl-N'-methyl-N-phenylhydrazinecarbonyl)-N,N-dimethylformamide;2-(2-acetyl-2-methyl-1-phenylhydrazinyl)-N,N-dimethyl-2-oxoacetamide

Chemical Property of Dioxypyramidon

Chemical Property:

• Melting Point: 105.5° (softens at 96°)
• Refractive Index: 1.5700 (estimate)
• Boiling Point: 360.6°Cat760mmHg
• PKA: -0.84±0.50(Predicted)
• Flash Point: 146.3°C
• PSA: 60.93000
• Density: 1.219g/cm³
• LogP: 0.50110
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 263.12699141
• Heavy Atom Count: 19
• Complexity: 362

Purity/Quality:

98%min ^*data from raw suppliers

Dioxoaminopyrine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(=O)N(C)N(C1=CC=CC=C1)C(=O)C(=O)N(C)C
• Uses: A metabolite of 4-Dimethylaminoantipyrine (D460890), an antipyretic; analgesic.

Technology Process of Dioxypyramidon

There total 6 articles about Dioxypyramidon which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

aminopyrine (58-15-1) → Dimethylaminooxoessigsaeure-2-acetyl-2-methyl-1-phenylhydrazid (519-65-3)

Guidance literature:

With oxygen; methylene blue; at 20 ℃; for 6h; Irradiation;

DOI:10.1002/ardp.19883210109

Reference yield:

aminopyrine (58-15-1) → Dimethylaminooxoessigsaeure-2-acetyl-2-methyl-1-phenylhydrazid (519-65-3) + aminopyrine cation radical (58-15-1) + dioxypyramidone + aminopyrine dication

Guidance literature:

With sodium acetate buffer; hypochloric acid; at 25 ℃; pH=5.0; Further Variations:; Reagents; pH-values; Temperatures; Kinetics;

DOI:10.1021/tx00044a007

Reference yield:

dimethylcarbamoylformylchloride (50680-54-1) + 1-acetyl-1-methyl-2-phenylhydrazine (38604-70-5) → Dimethylaminooxoessigsaeure-2-acetyl-2-methyl-1-phenylhydrazid (519-65-3)

Guidance literature:

upstream raw materials:

dimethylcarbamoylformylchloride

1-acetyl-1-methyl-2-phenylhydrazine

aminopyrine

dihydrogen peroxide

Downstream raw materials:

oxalic acid

1-methyl-2-phenylhydrazine

acetic acid

dimethyl amine

Refernces

• 1、 Duchstein, Hans-Juergen,Ruch-Zaske, Gabriela,Holzmann, Gerhard,Wollenberg, Eva,Weber, Horst. "Reaction of 1O2 with 4-Amino-3-pyrazolin-5-ones". . p. 25 - 27. Retrieved 2007/10/02.
• 2、 Marciniec. "Photochemical decomposition of phenazone derivatives. Part 5: Isolation and identification of decomposition products in aqueous solution". . p. 30 - 33. Retrieved 2007/10/02.