2-(Dimethylamino)-2-oxoacetyl chloride

Base Information

• Chemical Name: 2-(Dimethylamino)-2-oxoacetyl chloride
• CAS No.: 50680-54-1
• Molecular Formula: C4H6ClNO2
• Molecular Weight: 135.55
• European Community (EC) Number: 896-485-9
• DSSTox Substance ID: DTXSID50516742
• Nikkaji Number: J1.989.717F
• Wikidata: Q82378297
• Mol file: 50680-54-1.mol

Synonyms:2-(dimethylamino)-2-oxoacetyl chloride;50680-54-1;SCHEMBL359839;DTXSID50516742;DJSSLRVAYVVBLQ-UHFFFAOYSA-N;(Dimethylamino)(oxo)acetyl chloride;(DIMETHYLCARBAMOYL)CARBONYL CHLORIDE;EN300-7593081

Chemical Property of 2-(Dimethylamino)-2-oxoacetyl chloride

Chemical Property:

• Vapor Pressure: 1.65mmHg at 25°C
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 135.0087061
• Heavy Atom Count: 8
• Complexity: 121

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C(=O)C(=O)Cl

Technology Process of 2-(Dimethylamino)-2-oxoacetyl chloride

There total 6 articles about 2-(Dimethylamino)-2-oxoacetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N,N-dimethyloxamic acid (32833-96-8) → dimethylcarbamoylformylchloride (50680-54-1)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 3h;

Reference yield:

oxalyl dichloride (79-37-8) + N,N-dimethylammonium chloride (506-59-2) → dimethylcarbamoylformylchloride (50680-54-1)

Guidance literature:

In tetrachloromethane; at 65 ℃; for 18h;

DOI:10.1021/jo8005396

Reference yield:

oxalyl dichloride (79-37-8) + dimethyl amine (124-40-3) → dimethylcarbamoylformylchloride (50680-54-1)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

upstream raw materials:

dichloro-methoxy-acetic acid dimethylamide

ethoxy-dichloro-acetic acid dimethylamide

oxalyl dichloride

dimethyl amine

Downstream raw materials:

Dimethylaminooxoessigsaeure-2-acetyl-2-methyl-1-phenylhydrazid

dimethyl-oxalamic acid-(4-nitro-phenyl ester)

dimethyl-oxalamic acid phenyl ester

methyl 2-(dimethylamino)-2-oxoacetate