2-Methoxyethyl acetate

Base Information

• Chemical Name: 2-Methoxyethyl acetate
• CAS No.: 110-49-6
• Molecular Formula: C5H10 O3
• Molecular Weight: 118.133
• Hs Code.: 2915 39 00
• European Community (EC) Number: 203-772-9
• ICSC Number: 0476
• UN Number: 1189
• UNII: I62493E04O
• DSSTox Substance ID: DTXSID2025553
• Nikkaji Number: J5.093H
• Wikidata: Q2415195
• Mol file: 110-49-6.mol

Synonyms:2-methoxyethanol acetate;ethylene glycol monomethyl ether acetate

Chemical Property of 2-Methoxyethyl acetate

Chemical Property:

• Appearance/Colour: Colorless Liquid
• Vapor Pressure: 2.14mmHg at 25°C
• Melting Point: ?65 °C(lit.)
• Refractive Index: n20/D 1.402(lit.)
• Boiling Point: 143.2 °C at 760 mmHg
• Flash Point: 43.9 °C
• PSA: 35.53000
• Density: 1.009 g/mL at 25 °C(lit.)
• LogP: 0.19590
• Storage Temp.: Store below +30°C.
• Solubility.: Soluble in alcohol and ether (Weast, 1986).
• Water Solubility.: Miscible (Lyman et al., 1982)
• XLogP3: 0
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 118.062994177
• Heavy Atom Count: 8
• Complexity: 70.1
• Transport DOT Label: Flammable Liquid

Purity/Quality:

98%min ^*data from raw suppliers

2-Methoxyethyl Acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 60-61-20/21/22
• Safety Statements: 53-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Solvents -> Glycol Ethers (E Series)
• Canonical SMILES: CC(=O)OCCOC
• Inhalation Risk: A harmful contamination of the air can be reached rather quickly on evaporation of this substance at 20 °C.
• Effects of Short Term Exposure: The vapour is mildly irritating to the eyes. The substance may cause effects on the bone marrow and central nervous system. The substance may cause effects on the blood at high levels. This may result in lesions of blood cells and kidney impairment. Exposure far above the OEL could cause unconsciousness.
• Effects of Long Term Exposure: The substance defats the skin, which may cause dryness or cracking. The substance may have effects on the bone marrow and blood. This may result in lesions of blood cells and kidney impairment. May cause toxicity to human reproduction or development.
• Physical properties: Colorless liquid with a mild, ether-like odor. Experimentally determined detection and recognition odor threshold concentrations were 1.6 mg/m3 (330 ppbv) and 3.1 mg/m3 (640 ppbv), respectively (Hellman and Small, 1974).
• Uses: Lacquer industry; textile printing; manufacture of photographic film, coatings, and adhesives Industrial solvent.

Technology Process of 2-Methoxyethyl acetate

There total 9 articles about 2-Methoxyethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

2-(2-methoxy-ethoxy)-tetrahydro-pyran (4819-82-3) + ethyl acetate (141-78-6) → 2-methoxyethyl acetate (110-49-6)

Guidance literature:

With indium (III) iodide; for 12h; Heating;

DOI:10.1039/b100014b DOI:10.1039/b104055n

Reference yield: 42.0%

styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + diazoacetic acid ethyl ester (623-73-4) + methanol (67-56-1) → 2-methoxyethyl acetate (110-49-6) + ethyl rac-(1S,2S)-2-phenylcycloproanecarboxylate (946-39-4) + cis-1-ethoxycarbonyl-2-phenylcyclopropane (946-38-3) + diethyl Fumarate (623-91-6) + Diethyl maleate (141-05-9)

Guidance literature:

With (tetra-n-butylammonium)4-[γ-H2SiW10O36Cu(II)2(μ-1,1-N3)2]; at 59.84 ℃; under 760.051 Torr; optical yield given as %de; chemoselective reaction; Inert atmosphere;

DOI:10.1246/cl.2010.702

Reference yield:

2-methoxy-ethanol (109-86-4,95507-80-5) + acetic acid (64-19-7,77671-22-8) → 2-methoxyethyl acetate (110-49-6)

Guidance literature:

With toluene-4-sulfonic acid; man entfernt das entstehende Wasser durch azeotrope Destillation mit Benzol;

upstream raw materials:

diazomethane

2-hydroxyethyl acetate

Ketene

2-methoxy-ethanol

Downstream raw materials:

methoxyethene

2-methoxy-ethanol

Refernces

• 1、 Vojtko, Jan,Tomcik, Peter. "A method for esterification reaction rate prediction of aliphatic monocarboxylic acids with primary alcohols in 1,4-dioxane based on two parametrical taft equation". . p. 189 - 196. Retrieved 2014/02/14.
• 2、 Kamata, Keigo,Kimura, Toshihiro,Mizuno, Noritaka. "Cyclopropanation of olefins with diazo compounds catalyzed by a dicopper-substituted silicotungstate [γ-H2SiW 10O36Cu2(μ-1,1-N3) 2]4-". supporting information; scheme or table. p. 702 - 703. Retrieved 2011/01/08.