5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid methyl ester

Base Information

• Chemical Name: 5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid methyl ester
• CAS No.: 1186210-21-8
• Molecular Formula: C₁₂H₁₂N₂O₃
• Molecular Weight: 232.239
• Mol file: 1186210-21-8.mol

Synonyms:5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid methyl ester

Chemical Property of 5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid methyl ester

There total 1 articles about 5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methanol (67-56-1) + 4-(bis-methylsulfanyl-methylene)-5-methyl-2-phenyl-2,4-dihydropyrazol-3-one (19551-59-8) → 5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid methyl ester (1186210-21-8)

Guidance literature:

methanol; 4-(bis-methylsulfanyl-methylene)-5-methyl-2-phenyl-2,4-dihydropyrazol-3-one; With sodium ethanolate; at 80 ℃; for 2h;

With hydrogenchloride; In water;

DOI:10.1007/s00044-011-9774-2

Reference yield: 78.9%

5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid methyl ester (1186210-21-8) + ethylene dibromide (106-93-4) → 5-(2-bromoethoxy)-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid methyl ester (1248591-75-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 48h;

DOI:10.1248/cpb.58.634

Reference yield: 72.73%

5-hydroxy-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid methyl ester (1186210-21-8) + 1,3-dibromo-propane (109-64-8) → 5-(3-bromo-propoxy)-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid methyl ester (1229758-12-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 30h;

DOI:10.3998/ark.5550190.0011.911

upstream raw materials:

methanol

4-(bis-methylsulfanyl-methylene)-5-methyl-2-phenyl-2,4-dihydropyrazol-3-one

Downstream raw materials:

5-(2-bromoethoxy)-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid methyl ester

5-(3-bromo-propoxy)-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid methyl ester

5-[3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propoxy]-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid methyl ester

5-(3-benzimidazol-1-yl-propoxy)-3-methyl-1-phenyl-1H-pyrazole-4-carboxylic acid methyl ester