4α-acetoxy-2α-benzoyIoxy-5β,20-epoxy-1β,13α-dihydroxy-10β-methoxy-9-oxo-7β-triethylsilyloxy-11-taxene

Base Information

• Chemical Name: 4α-acetoxy-2α-benzoyIoxy-5β,20-epoxy-1β,13α-dihydroxy-10β-methoxy-9-oxo-7β-triethylsilyloxy-11-taxene
• CAS No.: 160084-70-8
• Molecular Formula: C₃₆H₅₂O₁₀Si
• Molecular Weight: 672.888

Synonyms:4α-acetoxy-2α-benzoyIoxy-5β,20-epoxy-1β,13α-dihydroxy-10β-methoxy-9-oxo-7β-triethylsilyloxy-11-taxene

Chemical Property of 4α-acetoxy-2α-benzoyIoxy-5β,20-epoxy-1β,13α-dihydroxy-10β-methoxy-9-oxo-7β-triethylsilyloxy-11-taxene

Chemical Property:

Purity/Quality:

98% HPLC ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4α-acetoxy-2α-benzoyIoxy-5β,20-epoxy-1β,13α-dihydroxy-10β-methoxy-9-oxo-7β-triethylsilyloxy-11-taxene

There total 8 articles about 4α-acetoxy-2α-benzoyIoxy-5β,20-epoxy-1β,13α-dihydroxy-10β-methoxy-9-oxo-7β-triethylsilyloxy-11-taxene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.6%

7-triethylsilyl-10-deacetylbaccatin III (115437-18-8) + methyl iodide (74-88-4) → 4α-acetoxy-2α-benzoyIoxy-5β,20-epoxy-1β,13α-dihydroxy-10β-methoxy-9-oxo-7β-triethylsilyloxy-11-taxene (160084-70-8)

Guidance literature:

7-triethylsilyl-10-deacetylbaccatin III; With lithium hexamethyldisilazane; In tetrahydrofuran; at -40 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; at 0 ℃; for 3h; Inert atmosphere;

Reference yield:

7-triethylsilyl-10-deacetylbaccatin III (115437-18-8) + methyl trifluoromethanesulfonate (333-27-7) → 4α-acetoxy-2α-benzoyIoxy-5β,20-epoxy-1β,13α-dihydroxy-10β-methoxy-9-oxo-7β-triethylsilyloxy-11-taxene (160084-70-8)

Guidance literature:

With lithium hexamethyldisilazane; In tetrahydrofuran; at -72 ℃; Inert atmosphere;

DOI:10.1016/j.bmc.2013.11.037

Reference yield:

7-triethylsilyl-10-deacetylbaccatin III (115437-18-8) + dimethyl sulfate (77-78-1) → 4α-acetoxy-2α-benzoyIoxy-5β,20-epoxy-1β,13α-dihydroxy-10β-methoxy-9-oxo-7β-triethylsilyloxy-11-taxene (160084-70-8)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at -20 ℃; for 2h;

upstream raw materials:

7-triethylsilyl-10-deacetylbaccatin III

methyl iodide

triethylsilyl chloride

10-deacetylbaccatin III

Downstream raw materials:

4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-10β-methoxy-9-oxo-1β,13α,7β-trihydroxy-11-taxene

4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β-hydroxy-7β,10β-dimethoxy-9-oxo-11-taxene-13α-yl (2R,4S,5R)-3-tert-butoxycarbonyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylate

4α-acetoxy-2α-benzoyloxy-5β,20-epoxy-1β,13α-dihydroxy-7β,10β-dimethoxy-9-oxo-11-taxene

carbazitaxel

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 160084-70-8 4α-acetoxy-2α-benzoyIoxy-5β,20-epoxy-1β,13α-dihydroxy-10β-methoxy-9-oxo-7β-triethylsilyloxy-11-taxene

Send

Send

Metric Ton KG G Pound L ML

Send

Send