2-(Benzylideneamino)-4-phenylthiazole

Base Information

• Chemical Name: 2-(Benzylideneamino)-4-phenylthiazole
• CAS No.: 13148-56-6
• Molecular Formula: C16H12 N2 S
• Molecular Weight: 264.3449
• ChEMBL ID: CHEMBL95373
• Mol file: 13148-56-6.mol

Synonyms:BRN 0192142;2-(Benzylideneamino)-4-phenylthiazole;Thiazole, 2-(benzylideneamino)-4-phenyl-;2-27-00-00429 (Beilstein Handbook Reference);13148-56-6;CHEMBL95373;SCHEMBL17352070;BDBM246432;LS-150800;US9447057, 19

Chemical Property of 2-(Benzylideneamino)-4-phenylthiazole

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 450.483°C at 760 mmHg
• Flash Point: 226.244°C
• Density: 1.156g/cm³
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 264.07211956
• Heavy Atom Count: 19
• Complexity: 293

Purity/Quality:

99% ，98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C=NC2=NC(=CS2)C3=CC=CC=C3
• Isomeric SMILES: C1=CC=C(C=C1)/C=N/C2=NC(=CS2)C3=CC=CC=C3

Technology Process of 2-(Benzylideneamino)-4-phenylthiazole

There total 3 articles about 2-(Benzylideneamino)-4-phenylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-Amino-4-phenylthiazole (2010-06-2) + benzaldehyde (100-52-7) → N-[phenylmethylidene]-N-(4-phenyl-1,3-thiazol-2-yl)amine (13148-56-6)

Guidance literature:

In ethanol; cooling;

DOI:10.1023/B:RJAC.0000038813.35580.37

Reference yield:

acetophenone (98-86-2) → N-[phenylmethylidene]-N-(4-phenyl-1,3-thiazol-2-yl)amine (13148-56-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 85 percent / iodine / 24 h / Heating

2: 69 percent / 0.5 h

With iodine;

DOI:10.1023/B:RUGC.0000025156.16373.17

Reference yield:

hydrogenchloride (7647-01-0,15364-23-5) + 2-Amino-4-phenylthiazole (2010-06-2) + ethanol (64-17-5) + benzaldehyde (100-52-7) → N-[phenylmethylidene]-N-(4-phenyl-1,3-thiazol-2-yl)amine (13148-56-6)

Guidance literature:

upstream raw materials:

2-Amino-4-phenylthiazole

benzaldehyde

hydrogenchloride

ethanol

Refernces

• 1、 Gupta, Ragini,Sharma, Deepti,Verma,Jain, Anshu. "Insecticidal Evaluation and [4+2] Aza-Diels-Alder Synthesis of 3,7-Diaryl-6,7-dihydro-5H-6-substituted Thiazolo[3,2-a]pyrimidin-5-ones Under Coupled Ultrasonic Irradiation and PTC". . p. 38 - 45. Retrieved 2016/02/10.
• 2、 Sadigova,Magerramov,Allakhverdiev,Vekilova. "Some transformations of 2-amino-4-phenyl-1,3-thiazole". . p. 787 - 789. Retrieved 2007/10/03.