N-Methylisopropylamine

Base Information

• Chemical Name: N-Methylisopropylamine
• CAS No.: 4747-21-1
• Molecular Formula: C4H11N
• Molecular Weight: 73.138
• Hs Code.: 29211990
• European Community (EC) Number: 225-266-7
• NSC Number: 1065
• UNII: J3OL90426G
• DSSTox Substance ID: DTXSID80871098
• Nikkaji Number: J121.770D
• Wikidata: Q27281162
• Mol file: 4747-21-1.mol

Synonyms:N-Isopropylmethylamine;4747-21-1;N-Methylisopropylamine;Methylisopropylamine;N-methylpropan-2-amine;2-Propanamine, N-methyl-;Isopropylmethylamine;2-Methylaminopropane;Methyl(Propan-2-Yl)Amine;Ethylamine, N,1-dimethyl-;N-Isopropyl-N-methylamine;isopropyl-methyl-amine;N-methyl-2-propanamine;N-methyl-N-isopropylamine;methyl(1-methylethyl)amine;UNII-J3OL90426G;J3OL90426G;NSC 1065;NSC-1065;EINECS 225-266-7;EC 225-266-7;N-methyl-N-[1-methylethyl]amine;N-Methyl-N-(1-methylethyl)amine;N-methylisopropyylamine;isopropylmethyamine;i-propylmethyl amine;isopropyl-methylamine;methyl isopropylamine;methyl-isopropylamine;methylisopropyl amine;MFCD00042859;NMIPA;isopropyl(methyl)amine;N-isopropyl-methylamine;N-methyl-isopropylamine;N-methylisopropyl amine;isopropyl(methyl)-amine;N,1-Dimethylethylamine;N-Methylpropan-2-amne;Ethylamine,1-dimethyl-;N-isopropyl-methyl-amine;N-methyl-iso-propylamine;N-isopropyl N-methylamine;N-Isopropyl-N-methylamine #;N-Isopropylmethylamine, 98%;2-(METHYLAMINO)PROPANE;DTXSID80871098;ISOPROPYLAMINE, N-METHYL-;NSC1065;AMY13353;STR05622;AKOS000120389;BP-13331;FT-0648300;M2429;EN300-20275;N-Isopropylmethylamine, purum, >=98.0% (GC);J-523732;Q27281162

Chemical Property of N-Methylisopropylamine

Chemical Property:

• Appearance/Colour: Colorless to light yellow liquid
• Vapor Pressure: 4.15 psi ( 20 °C)
• Melting Point: -55.1°C (estimate)
• Refractive Index: n20/D 1.384(lit.)
• Boiling Point: 43 °C at 760 mmHg
• PKA: 10.76±0.10(Predicted)
• Flash Point: ?25 °F
• PSA: 12.03000
• Density: 0.704 g/cm³
• LogP: 1.00510
• Storage Temp.: Refrigerator, Under Inert Atmosphere
• Sensitive.: Air Sensitive
• Solubility.: Soluble in chloroform, DMSO, methanol.
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 73.089149355
• Heavy Atom Count: 5
• Complexity: 17.6

Purity/Quality:

99.9% ^*data from raw suppliers

N-Isopropyl-N-methylamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,C
• Statements: 11-34
• Safety Statements: 16-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C)NC
• Uses: N-Isopropylmethylamine is used in the generation of in situ micelles having distinct sizes, by sequential self-assembly of a series of stimuli-responsive amphiphilic block copolymers, prepared by reversible addition-fragmentation chain transfer (RAFT) polymerization. It is suitable for use in the synthesis of novel 5-ethoxy-N,N-dialkyl-[α,α,β,β-H4]-tryptamines and their [α,α,β,β,β-D4]-counterparts following the Speeter and Anthony procedure.

Technology Process of N-Methylisopropylamine

There total 31 articles about N-Methylisopropylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.43%

isopropylamine (75-31-0) + carbonic acid dimethyl ester (616-38-6) → N-methylpropan-2-amine (4747-21-1)

Guidance literature:

With kaolin; for 18h; under 760.051 Torr; Reagent/catalyst; Reflux; Green chemistry;

Reference yield: 85.0%

acetone (67-64-1) + methylamine (74-89-5) → N-methylpropan-2-amine (4747-21-1)

Guidance literature:

With hydrogen; ZrO₂-containing catalyst; at 90 - 110 ℃; under 15001.5 Torr;

Reference yield: 80.0%

methanol (67-56-1) + 4-Methyl-benzenesulfinic acid isopropyl-methyl-amide (116560-15-7) → N-methylpropan-2-amine (4747-21-1) + methyl p-toluene sulfinate (672-78-6)

Guidance literature:

With tetraethylammonium tosylate; Electrochemical reaction; reticulated vitreous carbon anode; Pt cathode;

DOI:10.1021/ol0258381

upstream raw materials:

pyridine

N,N-dimethylisopropyl amine

dibenzoyl peroxide

nitromethane

Downstream raw materials:

N-isopropyl-N-methyl-β-alanine ethyl ester

O-(2,6-Dimethylphenyl)-N-isopropyl-N-methyl-(thiocarbamat)

3-(2,4-Dimethyl-phenyl)-1-isopropyl-1-methyl-thiourea

3-(4-Bromo-2-methyl-phenyl)-1-isopropyl-1-methyl-thiourea

Refernces

• 1、 Patil,Nandibewoor,Chimatadar. "Spectral and mechanistic investigations of ruthenium(III) catalyzed oxidation of atenolol by diperiodatocuprate(III) in aqueous alkaline medium 1". . p. 369 - 374. Retrieved 2012.
• 2、 Holzh?user, F. Joschka,Kurig, Nils,Mürtz, Sonja D.,Palkovits, Regina. "Reviving electrocatalytic reductive amination: A sustainable route from biogenic levulinic acid to 1,5-dimethyl-2-pyrrolidone". . p. 8428 - 8433. Retrieved 2021/11/17.
• 3、 Millet, Anthony,Dailler, David,Larini, Paolo,Baudoin, Olivier. "Ligand-controlled α- And β-arylation of acyclic N-boc amines". supporting information. p. 2678 - 2682. Retrieved 2014/03/21.