N′-(2-chloro-1-phenylethylidene)-4-methylbenzenesulfonohydrazide

Base Information

• Chemical Name: N′-(2-chloro-1-phenylethylidene)-4-methylbenzenesulfonohydrazide
• CAS No.: 71094-28-5
• Molecular Formula: C₁₅H₁₅ClN₂O₂S
• Molecular Weight: 322.815
• Mol file: 71094-28-5.mol

Synonyms:N′-(2-chloro-1-phenylethylidene)-4-methylbenzenesulfonohydrazide

Chemical Property of N′-(2-chloro-1-phenylethylidene)-4-methylbenzenesulfonohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N′-(2-chloro-1-phenylethylidene)-4-methylbenzenesulfonohydrazide

There total 2 articles about N′-(2-chloro-1-phenylethylidene)-4-methylbenzenesulfonohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

1-chloroacetophenone (532-27-4,108321-66-0,164322-25-2) + toluene-4-sulfonic acid hydrazide (1576-35-8) → N′-(2-chloro-1-phenylethylidene)-4-methylbenzenesulfonohydrazide (71094-28-5)

Guidance literature:

In diethyl ether; for 12h; Inert atmosphere;

DOI:10.1021/ja100932q

Reference yield:

acetophenone (98-86-2) → N′-(2-chloro-1-phenylethylidene)-4-methylbenzenesulfonohydrazide (71094-28-5)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid; N-chloro-succinimide

2: diethyl ether / 20 °C

With N-chloro-succinimide; toluene-4-sulfonic acid; In diethyl ether;

DOI:10.1021/acs.joc.8b01450

Reference yield: 89.0%

Nitrosobenzene (586-96-9) + N′-(2-chloro-1-phenylethylidene)-4-methylbenzenesulfonohydrazide (71094-28-5) → C21H19N3O3S

Guidance literature:

With sodium carbonate; In dichloromethane; at 20 ℃; for 24h;

upstream raw materials:

1-chloroacetophenone

toluene-4-sulfonic acid hydrazide

acetophenone

Downstream raw materials:

3-methyl-6-phenylpyridazine

4-methyl-6-phenylpyridazine

4-methyl-6-phenyl-4,5-dihydropyridazin-3(2H)-one

2-phenylthioacetophenone tosylhydrazone