2-(2-hydroxyethoxy)acetaldehyde

Base Information

• Chemical Name: 2-(2-hydroxyethoxy)acetaldehyde
• CAS No.: 17976-70-4
• Molecular Formula: C4H8O3
• Molecular Weight: 104.106
• Mol file: 17976-70-4.mol

Synonyms:Acetaldehyde,(2-hydroxyethoxy)- (8CI,9CI);(2-Hydroxyethoxy)acetaldehyde;2-(2-Hydroxyethoxy)acetaldehyde;

Chemical Property of 2-(2-hydroxyethoxy)acetaldehyde

Chemical Property:

• Vapor Pressure: 0.305mmHg at 25°C
• Refractive Index: 1.416
• Boiling Point: 178 °C at 760 mmHg
• PKA: 14.26±0.10(Predicted)
• Flash Point: 75.5 °C
• PSA: 46.53000
• Density: 1.087 g/cm³
• LogP: -0.80580

Purity/Quality:

99%, ^*data from raw suppliers

2-(2-HYDROXYETHOXY)ACETALDEHYDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-hydroxyethoxy)acetaldehyde

There total 6 articles about 2-(2-hydroxyethoxy)acetaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

diethylene glycol (111-46-6) → glycolic Acid (79-14-1) + ethylene glycol monoformate (628-35-3) + 2-(2-hydroxyethoxy)acetaldehyde (17976-70-4) + ethylene glycol (107-21-1) + Glycolaldehyde (141-46-8) + diethylene glycol monoformate (54229-31-1)

Guidance literature:

With air; at 120 ℃; Rate constant; Product distribution; Mechanism; further temperatures;

Reference yield:

α-acetoxy-N-nitrosomorpholine → 2-(2-hydroxyethoxy)acetaldehyde (17976-70-4) + acetaldehyde (75-07-0,9002-91-9) + Glycolaldehyde (141-46-8)

Guidance literature:

With Dimethylarsinic acid; potassium chloride; at 25 ℃; pH=5.16; Further Variations:; Reagents; pH-values; Kinetics;

DOI:10.1021/jo051936z

Reference yield:

diethylene glycol (111-46-6) → 2-(2-hydroxyethoxy)acetaldehyde (17976-70-4)

Guidance literature:

With benzophenone; bis(cyclopentadienyl)dihydrozirconium; at 170 ℃; for 10h;

DOI:10.1055/s-1986-31775

upstream raw materials:

1,4-dioxene

diethylene glycol

2-(2,2-diethoxyethoxy)ethan-1-ol

water

Downstream raw materials:

Quetiapine

C₁₀H₁₂N₄O₆

(2-hydroxy-ethoxy)-acetaldehyde-(2,4-dinitro-phenylhydrazone)

Refernces

• 1、 Zink, Charles N.,Kim, Hyun-Joong,Fishbein, James C.. "Synthesis and aqueous chemistry of α-acetoxy-N-nitrosomorpholine: Reactive intermediates and products". . p. 202 - 209. Retrieved 2007/10/03.
• 2、 Tsivunin, V. S.,Nasybullin, Sh. A.,Zaripova, V. G.,Ismagilov, R. M.,Zaripov, I. N.. "KINETICS OF THE HYDROLYSIS OF 1,4-DIOXENE IN AQUEOUS 1-PROPANOL". . p. 1379 - 1382. Retrieved 2007/10/02.