Technology Process of methyl 2-[(tert-butoxycarbonyl)amino]-4-(2-chlorophenyl)butanoate
There total 4 articles about methyl 2-[(tert-butoxycarbonyl)amino]-4-(2-chlorophenyl)butanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-tert-butoxycarbonylamino-4-(2-chlorophenyl)butyric acid;
With
dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
In
dichloromethane;
for 0.0833333h;
methanol;
In
dichloromethane;
for 3h;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: tetrabutyl-ammonium chloride; sodium hydrogencarbonate / palladium diacetate / N,N-dimethyl-formamide / 24 h / 30 °C / Inert atmosphere
2.1: zinc(II) iodide / diethyl ether / 0.25 h
2.2: 5 h / 50 °C
3.1: hydrogenchloride; water / 12 h / 100 °C
3.2: 2 h
3.3: pH 4
4.1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.08 h
4.2: 3 h
With
hydrogenchloride; dmap; tetrabutyl-ammonium chloride; water; sodium hydrogencarbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
palladium diacetate; zinc(II) iodide;
In
diethyl ether; dichloromethane; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: zinc(II) iodide / diethyl ether / 0.25 h
1.2: 5 h / 50 °C
2.1: hydrogenchloride; water / 12 h / 100 °C
2.2: 2 h
2.3: pH 4
3.1: dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.08 h
3.2: 3 h
With
hydrogenchloride; dmap; water; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride;
zinc(II) iodide;
In
diethyl ether; dichloromethane;
