tert-butyl 2-{2-[3-(2,2-dimethylpropionylamino)-2-methoxycarbonylphenyl]-ethyl}-pyrrolidine-1-carboxylate

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Chemical Name:tert-butyl 2-{2-[3-(2,2-dimethylpropionylamino)-2-methoxycarbonylphenyl]-ethyl}-pyrrolidine-1-carboxylate
CAS No.:1411983-05-5
Molecular Formula:C₂₄H₃₆N₂O₅
Molecular Weight:432.56
Hs Code.:

Synonyms:tert-butyl 2-{2-[3-(2,2-dimethylpropionylamino)-2-methoxycarbonylphenyl]-ethyl}-pyrrolidine-1-carboxylate

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Chemical Property of tert-butyl 2-{2-[3-(2,2-dimethylpropionylamino)-2-methoxycarbonylphenyl]-ethyl}-pyrrolidine-1-carboxylate

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Technology Process of tert-butyl 2-{2-[3-(2,2-dimethylpropionylamino)-2-methoxycarbonylphenyl]-ethyl}-pyrrolidine-1-carboxylate

There total 7 articles about tert-butyl 2-{2-[3-(2,2-dimethylpropionylamino)-2-methoxycarbonylphenyl]-ethyl}-pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1411983-06-6
tert-butyl 2-[3-(2,2-dimethylpropionylamino)-2-methoxycarbonylphenyl-ethynyl]-pyrrolidine-1-carboxylate

: 1411983-05-5
tert-butyl 2-{2-[3-(2,2-dimethylpropionylamino)-2-methoxycarbonylphenyl]-ethyl}-pyrrolidine-1-carboxylate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; for 4h;

Reference yield:

: 3282-30-2
pivaloyl chloride

: 1411983-05-5
tert-butyl 2-{2-[3-(2,2-dimethylpropionylamino)-2-methoxycarbonylphenyl]-ethyl}-pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydrogencarbonate / ethyl acetate; water

2: pyridine / dichloromethane / 1 h / Cooling with ice

3: lithium chloride / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 95 °C / Inert atmosphere

4: hydrogen / palladium 10% on activated carbon / ethanol / 4 h

With pyridine; hydrogen; sodium hydrogencarbonate; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In ethanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 316141-37-4
(R)-2-ethynyl-1-pyrrolidinecarboxylic acid,1,1-dimethylethyl ester

: 1411983-05-5
tert-butyl 2-{2-[3-(2,2-dimethylpropionylamino)-2-methoxycarbonylphenyl]-ethyl}-pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 1 h / -78 - -30 °C / Inert atmosphere

1.2: -30 - -10 °C

2.1: lithium chloride / bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 1 h / 95 °C / Inert atmosphere

3.1: hydrogen / palladium 10% on activated carbon / ethanol / 4 h

With n-butyllithium; hydrogen; lithium chloride; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;