2-(4-Chlorophenyl)-N-(4-methylbenzyl)-N-(1-isopropylpiperidin-4-yl)-acetamide

Base Information

Chemical Name:2-(4-Chlorophenyl)-N-(4-methylbenzyl)-N-(1-isopropylpiperidin-4-yl)-acetamide
CAS No.:359879-81-5
Molecular Formula:C₂₄H₃₁ClN₂O
Molecular Weight:398.976
Hs Code.:

Synonyms:2-(4-Chlorophenyl)-N-(4-methylbenzyl)-N-(1-isopropylpiperidin-4-yl)-acetamide

Suppliers and Price of 2-(4-Chlorophenyl)-N-(4-methylbenzyl)-N-(1-isopropylpiperidin-4-yl)-acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 2-(4-Chlorophenyl)-N-(4-methylbenzyl)-N-(1-isopropylpiperidin-4-yl)-acetamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Hazard Codes:

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Technology Process of 2-(4-Chlorophenyl)-N-(4-methylbenzyl)-N-(1-isopropylpiperidin-4-yl)-acetamide

There total 5 articles about 2-(4-Chlorophenyl)-N-(4-methylbenzyl)-N-(1-isopropylpiperidin-4-yl)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 359878-09-4
N-((4-methylphenyl)methyl)-N-(1-piperidin-4-yl)-4-chlorophenylacetamide

: 75-26-3
isopropyl bromide

: 359879-81-5
2-(4-Chlorophenyl)-N-(4-methylbenzyl)-N-(1-isopropylpiperidin-4-yl)-acetamide

Guidance literature:: With triethylamine; In water; ethyl acetate; acetonitrile;

Reference yield:

: 104-84-7
para-methylbenzylamine

: 359879-81-5
2-(4-Chlorophenyl)-N-(4-methylbenzyl)-N-(1-isopropylpiperidin-4-yl)-acetamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium cyanoborohydride; acetic acid / methanol / 20 h / pH ~ 5

1.2: pH ~ 10

2.1: triethylamine / dichloromethane / 0.17 h / 0 °C

2.2: 1.25 h / 0 °C

3.1: potassium carbonate / methanol / 24 h / 40 °C

4.1: triethylamine / acetonitrile / 0.17 h

4.2: 24 h / 20 - 60 °C

With sodium cyanoborohydride; potassium carbonate; acetic acid; triethylamine; In methanol; dichloromethane; acetonitrile;