2-DIMETHYLAMINO-2-METHYL-1-PROPANOL

Base Information

• Chemical Name: 2-DIMETHYLAMINO-2-METHYL-1-PROPANOL
• CAS No.: 7005-47-2
• Deprecated CAS: 95327-58-5
• Molecular Formula: C6H15 N O
• Molecular Weight: 117.191
• Hs Code.: 2922199090
• European Community (EC) Number: 230-279-6
• NSC Number: 17706
• UNII: 6ZWG40UQ9E
• DSSTox Substance ID: DTXSID6044721
• Nikkaji Number: J50.973F
• Wikidata: Q27265796
• ChEMBL ID: CHEMBL3182117
• Mol file: 7005-47-2.mol

Synonyms:2-(Dimethylamino)-2-methyl-1-propanol;2-(Dimethylamino)-2-methylpropyl alcohol;2-(N,N-Dimethylamino)-2-methyl-1-propanol; DMAMP; DMAMP 80;N,N-Dimethyl-2-amino-2-methylpropan-1-ol; NSC 17706; T-Amine WR 500

Chemical Property of 2-DIMETHYLAMINO-2-METHYL-1-PROPANOL

Chemical Property:

• Vapor Pressure: 7.21hPa at 25℃
• Melting Point: 19°C
• Refractive Index: n20/D 1.447
• Boiling Point: 61°C20mm Hg
• PKA: 15.86±0.10(Predicted)
• Flash Point: 145°F
• PSA: 23.47000
• Density: 0.95g/mLat 20°C(lit.)
• LogP: 0.31890
• Water Solubility.: 1000g/L at 20℃
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 117.115364102
• Heavy Atom Count: 8
• Complexity: 68.9

Purity/Quality:

99.9% ^*data from raw suppliers

2-(Dimethylamino)-2-methylpropan-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34-35
• Safety Statements: 23-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(CO)N(C)C

Technology Process of 2-DIMETHYLAMINO-2-METHYL-1-PROPANOL

There total 4 articles about 2-DIMETHYLAMINO-2-METHYL-1-PROPANOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

→ 2-dimethylamino-2-methylpropan-1-ol (7005-47-2)

Guidance literature:

With 5percent silver supported on titanium oxide; at 25 ℃; for 10h; Inert atmosphere; Sealed tube; UV-irradiation;

Reference yield: 46.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-Amino-2-methyl-1-propanol (124-68-5) → 2-dimethylamino-2-methylpropan-1-ol (7005-47-2)

Guidance literature:

With formic acid; at 80 ℃; for 24h;

DOI:10.1021/ja030322d

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 2-nitro-2-methylpropanol (76-39-1) → 2-dimethylamino-2-methylpropan-1-ol (7005-47-2)

Guidance literature:

2-nitro-2-methylpropanol; With hydrogen;

formaldehyd;

upstream raw materials:

formaldehyd

2-Amino-2-methyl-1-propanol

2-nitro-2-methylpropanol

Downstream raw materials:

β-Hydroxy-tert-butyl-trimethylammonium-iodid

4-chloro-N-(1-((1-(2-cyano-4-(dimethylamino)-4-methylpent-2-enoyl)pyrrolidin-2-yl)methyl)-5-(((S)-3,3-dimethylbutan-2-ylamino)methyl)-1H-benzo[d]imidazol-2-yl)benzamide

allyl (2-(4-chlorobenzamido)-1-((1-(2-cyano-4-(dimethylamino)-4-methylpent-2-enoyl)pyrrolidin-2-yl)methyl)-1H-benzo[d]imidazol-5-yl)methyl-((S)-3,3-dimethylbutan-2-yl)carbamate

2-dimethylamino-2-methylpropyl (2S)-4-(2,5-difluorophenyl)-2-phenyl-2,5-dihydro-1H-pyrrole-1-carboxylate trifluoroacetic acid salt

Refernces

• 1、 -. "PROCESS FOR MAKING TERTIARY AMINOALCOHOL COMPOUNDS". Page/Page column 16. . Retrieved 2013/03/26.
• 2、 -. "Substituted heteroarylpiperidine derivatives as melanocortin-4 receptor modulators". Page/Page column 30. . Retrieved 2009/02/10.