3-dimethylamino-psi-saccharin

Base Information

• Chemical Name: 3-dimethylamino-psi-saccharin
• CAS No.: 22716-43-4
• Molecular Formula: C₉H₁₀N₂O₂S
• Molecular Weight: 210.257
• Hs Code.: 2934991000
• Mol file: 22716-43-4.mol

Synonyms:1,2-Benzisothiazole,3-(dimethylamino)-, 1,1-dioxide (6CI,8CI); NSC 331993

Chemical Property of 3-dimethylamino-psi-saccharin

Chemical Property:

• Vapor Pressure: 1.73E-05mmHg at 25°C
• Boiling Point: 364.1°Cat760mmHg
• Flash Point: 174°C
• PSA: 58.12000
• Density: 1.36g/cm³
• LogP: 1.21350

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-dimethylamino-psi-saccharin

There total 7 articles about 3-dimethylamino-psi-saccharin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

N,N-dimethylammonium chloride (506-59-2) + saccharin (81-07-2) → 3-dimethylamino-1,2-benzisothiazole-1,1-dioxide (22716-43-4)

Guidance literature:

With N,N-dimethyl-cyclohexanamine; phosphorus pentoxide; at 240 ℃; for 2h;

Reference yield: 51.0%

dimethyl amine (124-40-3) + 3-chloro-1,2-benzisothiazole 1,1-dioxide (567-19-1) → 3-dimethylamino-1,2-benzisothiazole-1,1-dioxide (22716-43-4)

Guidance literature:

In chloroform; at 20 ℃; Inert atmosphere;

DOI:10.1021/acsmedchemlett.7b00137

Reference yield:

1-methyl-piperazine (109-01-3) + saccharin (81-07-2) → 3-dimethylamino-1,2-benzisothiazole-1,1-dioxide (22716-43-4)

Guidance literature:

In N,N,N,N,N,N-hexamethylphosphoric triamide;

upstream raw materials:

N,N,N,N,N,N-hexamethylphosphoric triamide

saccharin

saccharin sodium salt

N,N-Dimethylcarbamoyl chloride

Downstream raw materials:

3-(pyrrolidin-1-yl)-1,2-benzothiazole 1,1-dioxide

Refernces

• 1、 Jensen, Klaus G.,Pedersen, Erik B.. "Phosphoramides, XIX. Phosphorus Pentoxide Amine Hydrochloride Reagents in the Synthesis of 3-Amino-1,2-benzisothiazole-1,1-dioxides and 3-Aminothienoisothiazole-1,1-dioxides". . p. 1640 - 1643. Retrieved 2007/10/02.
• 2、 MEHTA,HAMOR. "Saccharin derivatives. IV. Synthesis of 2-(diethylcarbamoyl)- and 2-(diethylthiocarbamoyl) saccharin, and related compounds.". . p. 672 - 675. Retrieved 2007/10/08.