4'-cyanoanisalacetophenone

Base Information

• Chemical Name: 4'-cyanoanisalacetophenone
• CAS No.: 5520-71-8
• Molecular Formula: C₁₇H₁₃NO₂
• Molecular Weight: 263.296
• Mol file: 5520-71-8.mol

Synonyms:4'-cyanoanisalacetophenone

Chemical Property of 4'-cyanoanisalacetophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of 4'-cyanoanisalacetophenone

There total 5 articles about 4'-cyanoanisalacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

carbon monoxide (201230-82-2) + 4-bromobenzenecarbonitrile (623-00-7) + 4-methoxyphenylacetylen (768-60-5) → (E)-4-(3-(4-methoxyphenyl)acryloyl)benzonitrile (5520-71-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; 1,4-di(diphenylphosphino)-butane; palladium dichloride; In N,N-dimethyl-formamide; at 120 ℃; for 36h; under 11400.8 Torr; Inert atmosphere; Autoclave;

DOI:10.1039/c4ob01263a

Reference yield: 53.0%

4-cyanobenzaldehyde (105-07-7) + 4-methoxyphenylacetylen (768-60-5) → (E)-4-(3-(4-methoxyphenyl)acryloyl)benzonitrile (5520-71-8)

Guidance literature:

With Mg₃Al-CO₃-layered double hydroxide; In toluene; at 120 ℃; for 16h; under 760.051 Torr; Inert atmosphere;

DOI:10.1021/acscatal.8b02832

Reference yield:

4-cyanophenyl methyl ketone (1443-80-7) + 4-methoxy-benzaldehyde (123-11-5) → (E)-4-(3-(4-methoxyphenyl)acryloyl)benzonitrile (5520-71-8)

Guidance literature:

With sodium ethanolate;

DOI:10.1021/ja01117a070

upstream raw materials:

4-cyanophenyl methyl ketone

4-methoxy-benzaldehyde

carbon monoxide

4-bromobenzenecarbonitrile

Downstream raw materials:

4-[(2S,3R)-3-(4-Methoxy-phenyl)-oxiranecarbonyl]-benzonitrile

Refernces

• 1、 Zhang, Sheng,Wang, Liangguang,Feng, Xiujuan,Bao, Ming. "Palladium-catalyzed carbonylative addition of aryl bromides to arylalkynes: A simple and efficient method for chalcone synthesis". supporting information. p. 7233 - 7237. Retrieved 2014/11/07.