1-chloroethyl chloroformate

Base Information

• Chemical Name: 1-chloroethyl chloroformate
• CAS No.: 100704-12-9
• Molecular Formula: C₃H₅ClO₂
• Molecular Weight: 108.525
• Mol file: 100704-12-9.mol

Synonyms:1-chloroethyl chloroformate

Chemical Property of 1-chloroethyl chloroformate

Chemical Property:

Purity/Quality:

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Technology Process of 1-chloroethyl chloroformate

There total 1 articles about 1-chloroethyl chloroformate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.6%

formic acid ethyl ester (109-94-4) → 2-chloroethyl formate (1487-43-0) + 1-chloroethyl chloroformate (100704-12-9) + chloroformic acid ethyl ester (541-41-3)

Guidance literature:

With chlorine; at 23.84 ℃; under 950 Torr; Temperature; Pressure; Kinetics; Inert atmosphere; UV-irradiation;

DOI:10.1021/acs.jpca.6b02767

Reference yield:

1-chloroethyl chloroformate (100704-12-9) + Cyclohexanecarboxylic acid (98-89-5) → N-[3(S)-1-(5-phenyltetrazol-2-yl)-2-oxo-5-methyl-3-hexyl] cyclohexanecarboxamide (352003-28-2)

Guidance literature:

With 4-methyl-morpholine; sodium chloride; sodium hydrogencarbonate; citric acid; In ice-water; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

2-Picolinic acid (98-98-6) + 1-chloroethyl chloroformate (100704-12-9) + 2-[4-(3-trifluoromethylphenyl)piperazin-1-yl]ethan-1-amine (27144-85-0) → N-(2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)picolinamide

Guidance literature:

With triethylamine; In dichloromethane;

upstream raw materials:

formic acid ethyl ester

Downstream raw materials:

N-[3(S)-1-(5-phenyltetrazol-2-yl)-2-oxo-5-methyl-3-hexyl] cyclohexanecarboxamide

J₉₀₀