N-methoxy-N-methyl-4-[(4-methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide

Base Information

Chemical Name:N-methoxy-N-methyl-4-[(4-methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide
CAS No.:251992-69-5
Molecular Formula:C₁₇H₁₆N₂O₂S₂
Molecular Weight:344.458
Hs Code.:

Synonyms:N-methoxy-N-methyl-4-[(4-methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide

Suppliers and Price of N-methoxy-N-methyl-4-[(4-methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-methoxy-N-methyl-4-[(4-methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide

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Technology Process of N-methoxy-N-methyl-4-[(4-methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide

There total 7 articles about N-methoxy-N-methyl-4-[(4-methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 79-37-8
oxalyl dichloride

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 251992-65-1
4-[(4-methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxylic acid

: 251992-69-5
N-methoxy-N-methyl-4-[(4-methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide

Guidance literature:: With triethylamine; In tetrahydrofuran; THF water; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 2457-47-8
3,5-dichloropyridine

: 251992-69-5
N-methoxy-N-methyl-4-[(4-methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: LDA / tetrahydrofuran / 0.5 h / -78 °C

1.2: 90 percent / tetrahydrofuran / 1.4 h / -78 °C

2.1: K₂CO₃ / dimethylformamide / 1.5 h / 0 - 20 °C

3.1: K₂CO₃ / dimethylformamide / 2 h / 60 °C

4.1: 93 percent / aq. LiOH / propan-2-ol / 1 h / 75 °C

5.1: oxalyl chloride; DMF / CH₂Cl₂ / 0.5 h / 20 °C

6.1: tetrahydrofuran / 0.5 h / 20 °C

With lithium hydroxide; oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm000452m

Reference yield:

: 136590-83-5
3,5-dichloropyridine-4-carboxaldehyde

: 251992-69-5
N-methoxy-N-methyl-4-[(4-methylphenyl)thio]thieno[2,3-c]pyridine-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: K₂CO₃ / dimethylformamide / 1.5 h / 0 - 20 °C

2: K₂CO₃ / dimethylformamide / 2 h / 60 °C

3: 93 percent / aq. LiOH / propan-2-ol / 1 h / 75 °C

4: oxalyl chloride; DMF / CH₂Cl₂ / 0.5 h / 20 °C

5: tetrahydrofuran / 0.5 h / 20 °C

With lithium hydroxide; oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; isopropyl alcohol;
DOI:10.1021/jm000452m