Bis(4-ethoxyphenyl)methanone

Base Information

• Chemical Name: Bis(4-ethoxyphenyl)methanone
• CAS No.: 5032-11-1
• Molecular Formula: C17H18 O3
• Molecular Weight: 270.328
• NSC Number: 97666
• DSSTox Substance ID: DTXSID00294700
• Nikkaji Number: J2.877.019G
• Wikidata: Q82034116
• Mol file: 5032-11-1.mol

Synonyms:bis(4-ethoxyphenyl)methanone;5032-11-1;4,4'-diethoxybenzophenone;NSC97666;NCIOpen2_006569;Oprea1_468465;bis(4-ethoxyphenyl)-methanone;SCHEMBL845348;DTXSID00294700;NSC-97666;AKOS003607104

Chemical Property of Bis(4-ethoxyphenyl)methanone

Chemical Property:

• Vapor Pressure: 4.09E-07mmHg at 25°C
• Boiling Point: 415.6°Cat760mmHg
• Flash Point: 196.8°C
• Density: 1.087g/cm³
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 270.125594432
• Heavy Atom Count: 20
• Complexity: 259

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=C(C=C1)C(=O)C2=CC=C(C=C2)OCC

Technology Process of Bis(4-ethoxyphenyl)methanone

There total 29 articles about Bis(4-ethoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-bromoethoxybenzene (588-96-5) + chloroformic acid ethyl ester (541-41-3) → 4,4'-diethoxybenzophenone (5032-11-1)

Guidance literature:

chloroformic acid ethyl ester; With cobalt 2,2'-bipyridine dibromide; 3-chloroprop-1-ene; trifluoroacetic acid; zinc; In acetonitrile; at 20 ℃; for 0.333333h;

4-bromoethoxybenzene; In acetonitrile; at 20 ℃; for 4.5h;

DOI:10.1002/ejoc.201600738

Reference yield: 82.0%

oxalyl dichloride (79-37-8) + tris-(4-ethoxy-phenyl)-bismuthine (90591-48-3) → 4,4'-diethoxybenzophenone (5032-11-1)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 80 ℃; for 4h; Inert atmosphere;

DOI:10.1016/j.tetlet.2010.07.074

Reference yield: 81.0%

ethyl bromide (74-96-4) + 4,4'-Dihydroxybenzophenone (611-99-4) → 4,4'-diethoxybenzophenone (5032-11-1)

Guidance literature:

With potassium carbonate; In acetone; at 55 ℃; for 36h;

upstream raw materials:

4-ethoxy-4'-bromo-benzophenone

bis-(4-ethoxy-phenyl)methane

4,4'-diethoxythiobenzophenone

2,2-bis-(4-ethoxy-phenyl)-1,1,1-tribromo-ethane

Downstream raw materials:

4,4'-diethoxy-benzhydrol

4,4'-diethoxy-3,3'-dinitro-benzophenone

2,4-dinitro-1-ethoxybenzene

9-[bis(4-methoxyphenyl)methylidene]-9H-fluorene

Refernces

• 1、 -. "Aggregation-induced red light emission material and preparation method thereof". Paragraph 0073; 0074. . Retrieved 2017/08/28.
• 2、 Rérat, Alice,Michon, Christophe,Agbossou-Niedercorn, Francine,Gosmini, Corinne. "Synthesis of Symmetrical Diaryl Ketones by Cobalt-Catalyzed Reaction of Arylzinc Reagents with Ethyl Chloroformate". . p. 4554 - 4560. Retrieved 2016/09/23.