1-(5-Phenyl-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl)ethanone

Base Information

Chemical Name:1-(5-Phenyl-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl)ethanone
CAS No.:69824-59-5
Molecular Formula:C₁₅H₁₄N₂OS
Molecular Weight:270.355
Hs Code.:
DSSTox Substance ID:DTXSID301320674
Nikkaji Number:J2.476.188F
ChEMBL ID:CHEMBL1528831

Synonyms:MLS001164979;CHEMBL1528831;DTXSID301320674;HMS2854P13;1-(5-phenyl-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl)ethanone;STK551773;AKOS005478794;WAY-272159;69824-59-5;SMR000540299;1-Acetyl-3-phenyl-5-(2-thienyl)-2-pyrazoline;1-[3-phenyl-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl]ethanone

Suppliers and Price of 1-(5-Phenyl-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl)ethanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(5-Phenyl-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl)ethanone

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:270.08268425
Heavy Atom Count:19
Complexity:376

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)N1C(CC(=N1)C2=CC=CC=C2)C3=CC=CS3

Technology Process of 1-(5-Phenyl-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl)ethanone

There total 3 articles about 1-(5-Phenyl-3-thiophen-2-yl-3,4-dihydropyrazol-2-yl)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 2910-81-8,22488-77-3,39511-11-0
3-(2'-thienyl)acrylophenone

: 1068-57-1
acetic acid hydrazide

: 69824-59-5
1-(3-phenyl-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone

Guidance literature:: With 1,3,4,6,7,8-hexahydro-2H-pyrimido[1,2-a]pyrimidine; In acetonitrile; at 60 ℃; for 24h; regioselective reaction; Inert atmosphere;
DOI:10.1039/b911577c

Reference yield: 61.0%

: 2910-81-8,22488-77-3,39511-11-0
3-(2'-thienyl)acrylophenone

: 64-19-7,77671-22-8
acetic acid

: 69824-59-5
1-(3-phenyl-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone

Guidance literature:: With hydrazine hydrate; Reflux;
DOI:10.1002/ardp.201400199

Reference yield:

: 98-03-3
thiophene-2-carbaldehyde

: 98-86-2
acetophenone

: 69824-59-5
1-(3-phenyl-5-(thiophen-2-yl)-4,5-dihydro-1H-pyrazol-1-yl)ethanone

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / methanol / 0 - 20 °C

2: hydrazine hydrate / Reflux

With hydrazine hydrate; sodium hydroxide; In methanol; 1: |Claisen-Schmidt Condensation;
DOI:10.1002/ardp.201400199