1-Chloro-2-ethoxybenzene

Base Information

• Chemical Name: 1-Chloro-2-ethoxybenzene
• CAS No.: 614-72-2
• Molecular Formula: C8H9ClO
• Molecular Weight: 156.612
• Hs Code.: 2909309090
• European Community (EC) Number: 210-392-7
• NSC Number: 6160
• DSSTox Substance ID: DTXSID40210328
• Nikkaji Number: J44.129E
• Wikidata: Q83085001
• Mol file: 614-72-2.mol

Synonyms:1-Chloro-2-ethoxybenzene;2-Chlorophenetole;614-72-2;o-Chlorophenetole;Benzene, 1-chloro-2-ethoxy-;Phenetole, o-chloro-;2-Chlorophenol ethyl ether;o-Chlorophenyl ethyl ether;1-chloro-2-ethoxy-benzene;EINECS 210-392-7;AI3-01056;2chloro-phenetol;2-chloro-phenetol;chloro-2-ethoxybenzene;SCHEMBL198741;IRYSAAMKXPLGAM-UHFFFAOYSA-;DTXSID40210328;NSC6160;NSC 6160;NSC-6160;MFCD00058930;AKOS005142959;CS-0322816;FT-0657623;D89218

Chemical Property of 1-Chloro-2-ethoxybenzene

Chemical Property:

• Melting Point: 190-191.5 °C
• Refractive Index: 1.51
• Boiling Point: 210 °C at 760 mmHg
• Flash Point: 82.3 °C
• PSA: 9.23000
• Density: 1.103 g/cm³
• LogP: 2.73870
• Storage Temp.: 2-8°C
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 156.0341926
• Heavy Atom Count: 10
• Complexity: 95.3

Purity/Quality:

99% ^*data from raw suppliers

2-Chlorophenetole ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=CC=C1Cl

Technology Process of 1-Chloro-2-ethoxybenzene

There total 10 articles about 1-Chloro-2-ethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

diethyl sulfate (64-67-5) + 2-monochlorophenol (95-57-8) → 1-chloro-2-ethoxybenzene (614-72-2)

Guidance literature:

With lithium hydroxide; In tetrahydrofuran; for 1h; Ambient temperature;

DOI:10.1016/S0040-4039(98)00885-5

Reference yield: 49.2%

Phenetole (103-73-1) → 1-chloro-4-ethoxybenzene (622-61-7) + 1-chloro-2-ethoxybenzene (614-72-2)

Guidance literature:

With lithium chloride; In N,N-dimethyl-formamide; at 30 ℃; Pt anode, graphite cathode, sintered glass diaphragm, 1.3 V vs. SCE, 965 C;

DOI:10.1246/cl.1981.661

Reference yield:

ethanol (64-17-5) + 1,2-dichloro-benzene (95-50-1) → 1-chloro-2-ethoxybenzene (614-72-2)

Guidance literature:

With potassium hydroxide; PEG-8000; at 150 ℃; for 6h; Yields of byproduct given;

DOI:10.1016/S0040-4020(01)91597-2

upstream raw materials:

2-monochlorophenol

O,O-diethyl benzylphosphonate

sodium 4-chlorophenolate

ortho-phenitidine

Downstream raw materials:

4-(4-ethoxy-3-chloro-phenyl)-4-oxo-butyric acid

4-ethoxy-3-chloro-benzophenone

2-(4-ethoxy-3-chloro-phenyl)-quinoline-4-carboxylic acid

Refernces

• 1、 Basak, Anindita,Nayak, Mrinal K.,Chakraborti, Asit K.. "Chemoselective O-methylation of phenols under non-aqueous condition". . p. 4883 - 4886. Retrieved 2007/10/03.
• 2、 Jaeger, David A.,Clennan, Malgorzata Wegrzyn,Leyden, Donald E.,Murthy, R. S. Shreedhara. "SELECTIVITY OF AROMATIC CHLORINATION REACTIONS WITHIN A REVERSED-PHASE LIQUID CHROMATOGRAPHY COLUMN". . p. 4805 - 4808. Retrieved 2007/10/02.