CAS No.67-48-1,Choline chloride Suppliers

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Basic Information

Molecular Structure:
CAS No.:	67-48-1
Name:	Choline chloride
Article Data:	39

Formula:	C₅H₁₄ClNO
Molecular Weight:	139.625
Synonyms:	Choline hydrochloride;Choline chloride solutions;(2-Hydroxyethyl)trimethylammonium chloride;Cholinum;Ethanaminium, 2-hydroxy-N,N, N-trimethyl-, chloride;Hormocline;Colina cloruro [DCIT];2-Hydroxy-N,N,N-trimethylethanaminium chloride;Ammonium, (2-hydroxyethyl)trimethyl-, chloride;2-Hydroxy-N,N,N-trimethylethanaminium;Cholinium chloride;sell choline chloride;Bilineurin chloride;Ethanaminium, 2-hydroxy-N,N,N-trimethyl-;Paresan;2-hydroxyethyl-trimethyl-azanium;Neocolina;Choline chlorhydrate;Lipotril;2-Hydroxy-N,N,N-trimethylammonium chloride;Choline, chloride;Chloride de choline [French];Chlorure de choline [INN-French];Biocolina;Cholini chloridum [INN-Latin];2-hydroxyethyl-trimethyl-azanium chloride;
EINECS:	200-655-4
Density:	1.205 g/cm3
Melting Point:	302-305 °C (dec.)(lit.)
Solubility:	soluble in water
Appearance:	White crystalline powder
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26-36
PSA:	20.23000
LogP:	-3.31110

Synthetic route

: 75-21-8
oxirane

: 593-81-7
trimethylamine hydrochloride

: 67-48-1
choline chloride

Conditions

Conditions	Yield
With sodium hydroxide at 24.9℃; Thermodynamic data; ΔrH1;	100%
With sodium hydroxide at 24.9℃;	100%

: 107-07-3
2-chloro-ethanol

: 75-50-3
trimethylamine

: 67-48-1
choline chloride

Conditions

Conditions	Yield
In methanol; acetonitrile at 70℃; for 14h; Inert atmosphere;	98%
at 80℃;
With water

: 64-17-5
ethanol

: C25H25Cl2N2O3(1+)*Cl(1-)

A: ethyl 3-amino-1-(2,4-dichlorophenyl)-1H-benzo[f]chromene-2-carboxylate

B: 67-48-1
choline chloride

Conditions

Conditions	Yield
With diethylamine at 40℃; for 9h;	A 88% B n/a

...Expand

: 64-17-5
ethanol

: C25H26BrN2O3(1+)*Cl(1-)

A: 330957-88-5
ethyl 3-amino-1-(4-bromo phenyl)-1H-benzo[f]chromene-2-carboxylate

B: 67-48-1
choline chloride

Conditions

Conditions	Yield
With diethylamine at 40℃; for 9h;	A 84% B n/a

...Expand

: 64-17-5
ethanol

: C25H26N3O5(1+)*Cl(1-)

A: 299937-04-5
ethyl 3-amino-1-(3-nitrophenyl)-1H-benzo[f]chromene-2-carboxylate

B: 67-48-1
choline chloride

Conditions

Conditions	Yield
With diethylamine at 40℃; for 10h;	A 83% B n/a

...Expand

: 64-17-5
ethanol

: C25H26N3O5(1+)*Cl(1-)

A: 330957-87-4
ethyl 3-amino-1-(4-nitro phenyl)-1H-benzo[f]chromene-2-carboxylate

B: 67-48-1
choline chloride

Conditions

Conditions	Yield
With diethylamine at 40℃; for 10h;	A 74% B n/a

...Expand

: 64-17-5
ethanol

: C26H29N2O4(1+)*Cl(1-)

A: 67-48-1
choline chloride

B: 119825-14-8
ethyl 3-amino-1-(4-methoxyphenyl)-1H-benzo[f]chromene-2-carboxylate

Conditions

Conditions	Yield
With diethylamine at 40℃; for 11h;	A n/a B 73%

...Expand

: 64-17-5
ethanol

: C25H26ClN2O3(1+)*Cl(1-)

A: 67-48-1
choline chloride

B: 130944-14-8
ethyl 3-amino-1-(4-chlorophenyl)-1H-benzo[f]chromene-2-carboxylate

Conditions

Conditions	Yield
With diethylamine at 40℃; for 10h;	A n/a B 70%

...Expand

: 64-17-5
ethanol

: C25H26N3O5(1+)*Cl(1-)

A: 405109-32-2
ethyl 3-amino-1-(2-nitrophenyl)-1H-benzo[f]chromene-2-carboxylate

B: 67-48-1
choline chloride

Conditions

Conditions	Yield
With diethylamine at 40℃; for 10h;	A 70% B n/a

...Expand

: 64-17-5
ethanol

: C26H26N3O3(1+)*Cl(1-)

A: 405109-16-2
C23H18N2O3

B: 67-48-1
choline chloride

Conditions

Conditions	Yield
With diethylamine at 40℃; for 11h;	A 68% B n/a

...Expand

Raw Materials

107-73-3

107-07-3

75-21-8

2758-06-7

7647-01-0

593-81-7

74-88-4

64-17-5

Downstream Products

106-98-9

79-14-1

60-31-1

107-43-7

2758-06-7

64-18-6

590-18-1

593-79-3

Total:329 Page 1 of 9 1 2 3 4 5 6 …9 Next>>

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Chemistry

Structure of Choline chloride (CAS NO.67-48-1):

IUPAC Name: 2-hydroxyethyl(trimethyl)azanium chloride
Empirical Formula: C₅H₁₄ClNO
Molecular Weight: 139.6238
EINECS: 200-655-4
Melting point: 298-304 ºC
Water solubility: soluble
Sensitive: Hygroscopic
Physical Appearance: White crystalline powder
Product Categories: Quarternary ammonium salts;Ammonium Chlorides (Quaternary);Biochemistry;Quaternary Ammonium Compounds;Vitamin Related Compounds;Vitamins;Antioxidants;Intermediates & Fine Chemicals;Pharmaceuticals
Synonyms of Choline chloride (CAS NO.67-48-1): (2-Hydroxyethyl)trimethylammonium chloride ; (beta-Hydroxyethyl)trimethylammonium chloride ; 2-Hydroxy-N,N,N,-trimethylethanaminium chloride ; Ammonium, (2-hydroxyethyl)trimethyl-, chloride ; Bilineurin chloride ; Biocolina ; Biocoline ; Chloride de choline ; Choline chlorhydrate ; Choline hydrochloride ;
Cholini chloridum ; Cloruro de colina ; Colina cloruro ; Ethanaminium, 2-hydroxy-N,N,N-trimethyl-, chloride ; Hepacholine ;
Hormocline ; Lipotril ; Luridin chloride ; Trimethyl(2-hydroxyethyl)ammonium chloride .

Uses

Choline chloride (CAS NO.67-48-1) is an important additive in feed especially for chicken where it accelerates growth and is mass produced . With urea it forms a deep eutectic solvent. Other commercial choline salts are choline bitartrate choline and hydroxide . In foodstuffs the compound is often present as phosphatidylcholine.

Production

In the industrial Davy process choline chloride is produced from ethylene oxide, hydrochloric acid, and trimethylamine,[1] or from the pre-formed salt:

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LDLo	intravenous	25mg/kg (25mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
dog	LDLo	intravenous	5mg/kg (5mg/kg)		"Abdernalden's Handbuch der Biologischen Arbeitsmethoden." Vol. 4, Pg. 1289, 1935.
frog	LDLo	unreported	1500mg/kg (1500mg/kg)		Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
mouse	LD50	intraperitoneal	320mg/kg (320mg/kg)		Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
mouse	LD50	intravenous	53mg/kg (53mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 1016, 1983.
mouse	LD50	oral	3900mg/kg (3900mg/kg)	SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Arzneimittel-Forschung. Drug Research. Vol. 33, Pg. 1016, 1983.
mouse	LDLo	subcutaneous	735mg/kg (735mg/kg)		Journal of Pharmacology and Experimental Therapeutics. Vol. 6, Pg. 477, 1914/1915.
rabbit	LDLo	intraperitoneal	500mg/kg (500mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CORNEAL DAMAGE: EYE LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Infectious Diseases. Vol. 42, Pg. 473, 1928.
rabbit	LDLo	intravenous	1100ug/kg (1.1mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
rabbit	LDLo	rectal	1gm/kg (1000mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: CYANOSIS GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
rabbit	LDLo	subcutaneous	1gm/kg (1000mg/kg)		Proceedings of the Society for Experimental Biology and Medicine. Vol. 51, Pg. 281, 1942.
rat	LD50	intraperitoneal	450mg/kg (450mg/kg)		Indian Journal of Experimental Biology. Vol. 24, Pg. 91, 1986.
rat	LD50	oral	3400mg/kg (3400mg/kg)	SENSE ORGANS AND SPECIAL SENSES: CHROMODACYRORREA: EYE BEHAVIORAL: EXCITEMENT LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION	Proceedings of the Society for Experimental Biology and Medicine. Vol. 58, Pg. 87, 1945.

Safety Profile

Hazard Codes: Xi
The Risk Statements information of Choline chloride :
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of Choline chloride :
26: In case of contact with eyes, rinse immediately with plenty of WATER and seek medical advice
36: Wear suitable protective clothing
WGK Germany: 1
RTECS: KH2975000
F: 3-9