3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-N-methoxy-N-methylpropanamide

Base Information

Chemical Name:3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-N-methoxy-N-methylpropanamide
CAS No.:908275-28-5
Molecular Formula:C₁₇H₂₉NO₃Si
Molecular Weight:323.508
Hs Code.:

Synonyms:3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-N-methoxy-N-methylpropanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-N-methoxy-N-methylpropanamide

Chemical Property:

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Technology Process of 3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-N-methoxy-N-methylpropanamide

There total 3 articles about 3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-N-methoxy-N-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 114774-39-9
3-(4-((tert-butyldimethylsilyl)oxy)phenyl)propanoic acid

: 6638-79-5
N,O-dimethylhydroxylamine*hydrochloride

: 908275-28-5
3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-N-methoxy-N-methylpropanamide

Guidance literature:: With dmap; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;
DOI:10.1021/jacs.7b07830

Reference yield:

: 501-97-3
4-hydroxyphenylpropionic acid

: 908275-28-5
3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-N-methoxy-N-methylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: imidazole / dimethylformamide / 20 °C

1.2: K₂CO₃; H₂O / methanol; tetrahydrofuran

2.1: BOP; Et₃N / CH₂Cl₂ / 12 h / 20 °C

With 1H-imidazole; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja062508t

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 908275-28-5
3-(4-((tert-butyldimethylsilyl)oxy)phenyl)-N-methoxy-N-methylpropanamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: imidazole / dimethylformamide / 20 °C

1.2: K₂CO₃; H₂O / methanol; tetrahydrofuran

2.1: BOP; Et₃N / CH₂Cl₂ / 12 h / 20 °C

With 1H-imidazole; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja062508t