N-[4-chloro-2-(4-fluoro-benzoyl)-phenyl]-4-fluoro-benzamide

Base Information

• Chemical Name: N-[4-chloro-2-(4-fluoro-benzoyl)-phenyl]-4-fluoro-benzamide
• CAS No.: 869365-90-2
• Molecular Formula: C₂₀H₁₂ClF₂NO₂
• Molecular Weight: 371.771
• Mol file: 869365-90-2.mol

Synonyms:N-[4-chloro-2-(4-fluoro-benzoyl)-phenyl]-4-fluoro-benzamide

Chemical Property of N-[4-chloro-2-(4-fluoro-benzoyl)-phenyl]-4-fluoro-benzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[4-chloro-2-(4-fluoro-benzoyl)-phenyl]-4-fluoro-benzamide

There total 1 articles about N-[4-chloro-2-(4-fluoro-benzoyl)-phenyl]-4-fluoro-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

4-fluorobenzoyl chloride (403-43-0) + 4-chloro-aniline (106-47-8) → N-[4-chloro-2-(4-fluoro-benzoyl)-phenyl]-4-fluoro-benzamide (869365-90-2)

Guidance literature:

4-fluorobenzoyl chloride; 4-chloro-aniline; at 120 - 180 ℃; for 0.166667h;

zinc(II) chloride; at 180 - 205 ℃; for 2.16667h;

With hydrogenchloride; In water; at 120 ℃; for 1h;

Reference yield: 83.0%

methanol (67-56-1) + N-[4-chloro-2-(4-fluoro-benzoyl)-phenyl]-4-fluoro-benzamide (869365-90-2) → (2-amino-5-chlorophenyl)(4-methoxyphenyl)methanone (7497-59-8)

Guidance literature:

With sodium hydroxide; water; for 16h; Heating / reflux;

Reference yield: 76.0%

N-[4-chloro-2-(4-fluoro-benzoyl)-phenyl]-4-fluoro-benzamide (869365-90-2) → (2-amino-5-chlorophenyl)(4-fluorophenyl)methanone (784-40-7)

Guidance literature:

N-[4-chloro-2-(4-fluoro-benzoyl)-phenyl]-4-fluoro-benzamide; With water; acetic acid; hydrogenchloride; at 105 ℃; for 16h;

With sodium hydroxide; In dichloromethane; water;

upstream raw materials:

4-fluorobenzoyl chloride

4-chloro-aniline

Downstream raw materials:

(2-amino-5-chlorophenyl)(4-fluorophenyl)methanone

(2-amino-5-chlorophenyl)(4-methoxyphenyl)methanone