2-(4-{4-[N'-(2,4-dimethoxybenzylaminocarbonyl)hydrazino]-4-oxo-butyl}phenoxy)-2-methylpropionic acid tert-butyl ester

Base Information

Chemical Name:2-(4-{4-[N'-(2,4-dimethoxybenzylaminocarbonyl)hydrazino]-4-oxo-butyl}phenoxy)-2-methylpropionic acid tert-butyl ester
CAS No.:425672-69-1
Molecular Formula:C₂₈H₃₉N₃O₇
Molecular Weight:529.634
Hs Code.:

Synonyms:2-(4-{4-[N'-(2,4-dimethoxybenzylaminocarbonyl)hydrazino]-4-oxo-butyl}phenoxy)-2-methylpropionic acid tert-butyl ester

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Chemical Property of 2-(4-{4-[N'-(2,4-dimethoxybenzylaminocarbonyl)hydrazino]-4-oxo-butyl}phenoxy)-2-methylpropionic acid tert-butyl ester

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Technology Process of 2-(4-{4-[N'-(2,4-dimethoxybenzylaminocarbonyl)hydrazino]-4-oxo-butyl}phenoxy)-2-methylpropionic acid tert-butyl ester

There total 5 articles about 2-(4-{4-[N'-(2,4-dimethoxybenzylaminocarbonyl)hydrazino]-4-oxo-butyl}phenoxy)-2-methylpropionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 93489-13-5
1-(isocyanatomethyl)-2,4-dimethoxybenzene

: 425672-62-4
2-[4-(3-hydrazinocarbonylpropyl)phenoxy]-2-methylpropionic acid tert-butyl ester

: 425672-69-1
2-(4-{4-[N'-(2,4-dimethoxybenzylaminocarbonyl)hydrazino]-4-oxo-butyl}phenoxy)-2-methylpropionic acid tert-butyl ester

Guidance literature:: In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm034173l

Reference yield:

: 23877-12-5
tert-butyl bromoisobutyrate

: 425672-69-1
2-(4-{4-[N'-(2,4-dimethoxybenzylaminocarbonyl)hydrazino]-4-oxo-butyl}phenoxy)-2-methylpropionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 27 g / K₂CO₃; MgSO₄ / dimethylformamide / 75 °C

2: hydrazine hydrate / methanol / 20 °C

3: 67 percent / CH₂Cl₂ / 2 h / 20 °C

With magnesium sulfate; potassium carbonate; hydrazine hydrate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm034173l

Reference yield:

: 20637-08-5
4-(4-methoxyphenyl)butyric acid methyl ester

: 425672-69-1
2-(4-{4-[N'-(2,4-dimethoxybenzylaminocarbonyl)hydrazino]-4-oxo-butyl}phenoxy)-2-methylpropionic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: BBr₃ / CH₂Cl₂ / 1 h / 0 °C

2: 27 g / K₂CO₃; MgSO₄ / dimethylformamide / 75 °C

3: hydrazine hydrate / methanol / 20 °C

4: 67 percent / CH₂Cl₂ / 2 h / 20 °C

With boron tribromide; magnesium sulfate; potassium carbonate; hydrazine hydrate; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm034173l