acetic acid 2-cyano-1-[3-(2,4-dichlorophenyl)-5-methylisoxazol-4-yl]allyl ester

Base Information

Chemical Name:acetic acid 2-cyano-1-[3-(2,4-dichlorophenyl)-5-methylisoxazol-4-yl]allyl ester
CAS No.:635681-09-3
Molecular Formula:C₁₆H₁₂Cl₂N₂O₃
Molecular Weight:351.189
Hs Code.:

Synonyms:acetic acid 2-cyano-1-[3-(2,4-dichlorophenyl)-5-methylisoxazol-4-yl]allyl ester

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Chemical Property of acetic acid 2-cyano-1-[3-(2,4-dichlorophenyl)-5-methylisoxazol-4-yl]allyl ester

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Technology Process of acetic acid 2-cyano-1-[3-(2,4-dichlorophenyl)-5-methylisoxazol-4-yl]allyl ester

There total 4 articles about acetic acid 2-cyano-1-[3-(2,4-dichlorophenyl)-5-methylisoxazol-4-yl]allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 75-36-5
acetyl chloride

: 635680-66-9
2-{[3-(2,4-dichlorophenyl)-5-methylisoxazol-4-yl]hydroxymethyl}acrylonitrile

: 635681-09-3
acetic acid 2-cyano-1-[3-(2,4-dichlorophenyl)-5-methylisoxazol-4-yl]allyl ester

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 1h;
DOI:10.1055/s-2003-40204

Reference yield:

: 29203-60-9
2,4-dichloro-N-hydroxybenzenecarboximidoyl chloride

: 635681-09-3
acetic acid 2-cyano-1-[3-(2,4-dichlorophenyl)-5-methylisoxazol-4-yl]allyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaOMe / methanol

1.2: methanol / 4 h / 0 °C

2.1: 100 percent / LiAlH₄ / diethyl ether / 1 h / 40 °C

3.1: PCC / CH₂Cl₂ / 0.5 h / 20 °C

4.1: 79 percent / DABCO / 72 h / 20 °C

5.1: 86 percent / pyridine / CH₂Cl₂ / 1 h / 20 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; lithium aluminium tetrahydride; sodium methylate; pyridinium chlorochromate; In methanol; diethyl ether; dichloromethane; 4.1: Baylis-Hillman reaction;
DOI:10.1055/s-2003-40204

Reference yield:

: 4402-77-1
3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid methyl ester

: 635681-09-3
acetic acid 2-cyano-1-[3-(2,4-dichlorophenyl)-5-methylisoxazol-4-yl]allyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 100 percent / LiAlH₄ / diethyl ether / 1 h / 40 °C

2: PCC / CH₂Cl₂ / 0.5 h / 20 °C

3: 79 percent / DABCO / 72 h / 20 °C

4: 86 percent / pyridine / CH₂Cl₂ / 1 h / 20 °C

With pyridine; 1,4-diaza-bicyclo[2.2.2]octane; lithium aluminium tetrahydride; pyridinium chlorochromate; In diethyl ether; dichloromethane; 3: Baylis-Hillman reaction;
DOI:10.1055/s-2003-40204