2-{[3-(2,4-dichlorophenyl)-5-methylisoxazol-4-yl]hydroxymethyl}acrylonitrile

Base Information

Chemical Name:2-{[3-(2,4-dichlorophenyl)-5-methylisoxazol-4-yl]hydroxymethyl}acrylonitrile
CAS No.:635680-66-9
Molecular Formula:C₁₄H₁₀Cl₂N₂O₂
Molecular Weight:309.152
Hs Code.:

Synonyms:2-{[3-(2,4-dichlorophenyl)-5-methylisoxazol-4-yl]hydroxymethyl}acrylonitrile

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Chemical Property of 2-{[3-(2,4-dichlorophenyl)-5-methylisoxazol-4-yl]hydroxymethyl}acrylonitrile

Chemical Property:

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Technology Process of 2-{[3-(2,4-dichlorophenyl)-5-methylisoxazol-4-yl]hydroxymethyl}acrylonitrile

There total 4 articles about 2-{[3-(2,4-dichlorophenyl)-5-methylisoxazol-4-yl]hydroxymethyl}acrylonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 107-13-1,25014-41-9
acrylonitrile

: 635680-06-7
3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carbaldehyde

: 635680-66-9
2-{[3-(2,4-dichlorophenyl)-5-methylisoxazol-4-yl]hydroxymethyl}acrylonitrile

Guidance literature:: With 1,4-diaza-bicyclo[2.2.2]octane; at 20 ℃; for 72h;
DOI:10.1055/s-2003-40204

Reference yield:

: 29203-60-9
2,4-dichloro-N-hydroxybenzenecarboximidoyl chloride

: 635680-66-9
2-{[3-(2,4-dichlorophenyl)-5-methylisoxazol-4-yl]hydroxymethyl}acrylonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: NaOMe / methanol

1.2: methanol / 4 h / 0 °C

2.1: 100 percent / LiAlH₄ / diethyl ether / 1 h / 40 °C

3.1: PCC / CH₂Cl₂ / 0.5 h / 20 °C

4.1: 79 percent / DABCO / 72 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; lithium aluminium tetrahydride; sodium methylate; pyridinium chlorochromate; In methanol; diethyl ether; dichloromethane; 4.1: Baylis-Hillman reaction;
DOI:10.1055/s-2003-40204

Reference yield:

: 4402-77-1
3-(2,4-dichloro-phenyl)-5-methyl-isoxazole-4-carboxylic acid methyl ester

: 635680-66-9
2-{[3-(2,4-dichlorophenyl)-5-methylisoxazol-4-yl]hydroxymethyl}acrylonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 100 percent / LiAlH₄ / diethyl ether / 1 h / 40 °C

2: PCC / CH₂Cl₂ / 0.5 h / 20 °C

3: 79 percent / DABCO / 72 h / 20 °C

With 1,4-diaza-bicyclo[2.2.2]octane; lithium aluminium tetrahydride; pyridinium chlorochromate; In diethyl ether; dichloromethane; 3: Baylis-Hillman reaction;
DOI:10.1055/s-2003-40204