Oxygen-18O2

Base Information

• Chemical Name: Oxygen-18O2
• CAS No.: 32767-18-3
• Molecular Formula: O2
• Molecular Weight: 38.0159
• DSSTox Substance ID: DTXSID80437936
• Wikidata: Q82253542
• Mol file: 32767-18-3.mol

Synonyms:Oxygen-18O2;32767-18-3;DTXSID80437936;Oxygen-18O2, 90 atom % 18O;Oxygen-18O2, 97 atom % 18O;18O2;Oxygen-18O2, 10 atom % 18O (random);Oxygen-18O2, 25 atom % 18O (random);Oxygen-18O2, 50 atom % 18O (random);Oxygen-18O2, 99 atom % 18O, 99% (CP);Oxygen-18O2, 97 atom % 18O, 99.99% (CP)

Chemical Property of Oxygen-18O2

Chemical Property:

• Melting Point: −218 °C(lit.)
• Boiling Point: −183 °C(lit.)
• PSA: 34.14000
• Density: 1.11 (vs air)
• LogP: 0.06700
• XLogP3: -1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 35.99831922
• Heavy Atom Count: 2
• Complexity: 0

Purity/Quality:

99% ^*data from raw suppliers

Oxygen-18O2 99 atom % ^*data from reagent suppliers

Safty Information:

• Hazard Codes: O
• Statements: 8
• Safety Statements: 17

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: O=O
• Isomeric SMILES: [18O]=[18O]
• General Description: OXYGEN-18O2, 97 ATOM % 18O (also referred to as 18O2, Dioxygen-18, or Oxygen-18O2) is an isotopically labeled form of molecular oxygen used to trace the incorporation of aerobic oxygen into biochemical intermediates. In the study of peptidylglycine α-amidating monooxygenase (PAM), 18O2 was employed to demonstrate that the hydroxy group in the hydroxyglycyl intermediate originates primarily from molecular oxygen, supporting a direct hydroxylation mechanism rather than an N-acyl imine pathway. The observed 30% 18O incorporation into the product confirms the role of aerobic oxygen in the reaction.

Technology Process of Oxygen-18O2

There total 63 articles about Oxygen-18O2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

xenon difluoride (13709-36-9) + 18O-labeled water (14797-71-8) → oxygen-18 (32767-18-3)

Guidance literature:

In neat (no solvent, gas phase); byproducts: Xe, HF; at 50°C for 3 h; fractional distn. at low temp.;

DOI:10.1134/S0036023611030053

Reference yield:

water (7732-18-5) + 18O-labeled water (14797-71-8) → oxygen + hydrogen (1333-74-0) + oxygen (80937-33-3) + oxygen-18 (32767-18-3)

Guidance literature:

titanium disilicide; In water; Irradiation (UV/VIS); suspn. of TiSi2 in either tridistilled or tap water with 10% H2(18)O at pH 7 was irradiated at 50 to 85°C with stirring under N2 or Ar; gas chromy., mass-spectrometry;

DOI:10.1002/anie.200701626

Reference yield:

18O-labeled water (14797-71-8) → oxygen-18O,16O (17410-58-1) + oxygen (80937-33-3) + oxygen-18 (32767-18-3)

Guidance literature:

With Ce(IV); ([Ru(II)(2,2':6',2''-terpyridine)(H2(18)O)(μ-2,6-bis(pyridyl)pyrazolate))(3+); In further solvent(s); 0.1 M CF3SO3H in H2(18)O; Kinetics;

upstream raw materials:

ozone

water

¹⁸O-labeled water

cobalt(III)

Downstream raw materials:

dioxygen-⁽¹⁶⁾O

hydrogen peroxide

hydrogen peroxide

carbon dioxide

Refernces

Incorporation of Aerobic Oxygen into the Hydroxyglycyl Intermediate during Formation of C-Terminal Peptide Amides by Peptidylglycine α-Amidating Monooxygenase (PAM)

10.1039/c39910000571

The research investigates the mechanism of how peptidylglycine α-amidating monooxygenase (PAM) incorporates oxygen into the hydroxyglycyl intermediate during the formation of C-terminal peptide amides. The purpose is to determine whether the hydroxy group in the intermediate is formed by direct hydroxylation of carbon or via oxidative formation of an N-acyl imine followed by addition of water. The key chemicals used include D-phenylalanyl-L-phenylalanylglycine as the substrate, PAM enzyme, ascorbate, copper, molecular oxygen, and 18O2 for labeling. The study concludes that aerobic oxygen is the primary source of the hydroxy group, supporting the direct hydroxylation mechanism, as evidenced by the 30% 18O incorporation into the hydroxy group of the product when 18O2 was used in the reaction.