Methyl 2-(2-chlorophenoxy)acetate

Base Information

• Chemical Name: Methyl 2-(2-chlorophenoxy)acetate
• CAS No.: 6956-85-0
• Molecular Formula: C9H9 Cl O3
• Molecular Weight: 200.622
• NSC Number: 65094
• DSSTox Substance ID: DTXSID50989598
• Wikidata: Q82978784
• Mol file: 6956-85-0.mol

Synonyms:methyl 2-(2-chlorophenoxy)acetate;6956-85-0;methyl (2-chlorophenoxy)acetate;NSC65094;methyl o-chlorophenoxyacetate;NCIOpen2_003048;SCHEMBL5000478;DTXSID50989598;methyl2-(2-chlorophenoxy)acetate;MFCD08753709;NSC-65094;AKOS000295664;LS-08696;(2-chloro-phenoxy)-acetic acid methyl ester

Chemical Property of Methyl 2-(2-chlorophenoxy)acetate

Chemical Property:

• Vapor Pressure: 0.00966mmHg at 25°C
• Boiling Point: 264.5°Cat760mmHg
• Flash Point: 109.6°C
• Density: 1.239g/cm³
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 200.0240218
• Heavy Atom Count: 13
• Complexity: 172

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC(=O)COC1=CC=CC=C1Cl

Technology Process of Methyl 2-(2-chlorophenoxy)acetate

There total 7 articles about Methyl 2-(2-chlorophenoxy)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

glycolic acid methyl ester (96-35-5) + 1,2-dichloro-benzene (95-50-1) → Methyl (2-chlorophenoxy)acetate (6956-85-0)

Guidance literature:

glycolic acid methyl ester; With sodium methylate; at 20 ℃;

1,2-dichloro-benzene; at 60 ℃;

Reference yield: 95.0%

2-monochlorophenol (95-57-8) + bromoacetic acid methyl ester (96-32-2) → Methyl (2-chlorophenoxy)acetate (6956-85-0)

Guidance literature:

With potassium carbonate; In acetone; for 5h; Heating;

DOI:10.1021/tx025555h

Reference yield:

2-monochlorophenol (95-57-8) + methyl chloroacetate (96-34-4) → Methyl (2-chlorophenoxy)acetate (6956-85-0)

Guidance literature:

With potassium carbonate; potassium iodide; PEG-600; In N,N-dimethyl-formamide; for 0.0666667h; microwave irradiation;

upstream raw materials:

methanol

(2-chlorophenoxy)acetic acid

(2-chloro-phenoxy)-acetyl chloride

2-monochlorophenol

Downstream raw materials:

(2-chlorophenoxy)acetic acid

6-(2-chlorophenoxy)-8-methyl-2-(methylthio)-pyrido[2,3-d]pyrimidin-7(8H)-one

N,N'-bis-[(2-chloro-phenoxy)-acetyl]-hydrazine

(2-chlorophenoxy)acetic acid hydrazide

Refernces

• 1、 Lei, Kang,Li, Pan,Yang, Xue-Fang,Wang, Shi-Ben,Wang, Xue-Kun,Hua, Xue-Wen,Sun, Bin,Ji, Lu-Sha,Xu, Xiao-Hua. "Design and Synthesis of Novel 4-Hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one Derivatives for Use as Herbicides and Evaluation of Their Mode of Action". . p. 10489 - 10497. Retrieved 2019/10/02.
• 2、 Wei, Tai-Bao,Hua, Mao-Tang,Shi, Hai-Xiong,Liu, Yong,Zhang, You-Ming. "Aza-Michael addition of acrylonitrile with 2-aryloxymethylbenzimidazole derivatives under microwave irradiation". scheme or table. p. 452 - 454. Retrieved 2010/12/24.