3-methyl-1,4-diphenyl-7-thioxo-4,6,8,9-tetrahydropyrazolo[5,4-b]pyrimidino[5,4-e]pyridin-5-one

Base Information

• Chemical Name: 3-methyl-1,4-diphenyl-7-thioxo-4,6,8,9-tetrahydropyrazolo[5,4-b]pyrimidino[5,4-e]pyridin-5-one
• CAS No.: 1426333-78-9
• Molecular Formula: C₂₁H₁₇N₅OS
• Molecular Weight: 387.465

Synonyms:3-methyl-1,4-diphenyl-7-thioxo-4,6,8,9-tetrahydropyrazolo[5,4-b]pyrimidino[5,4-e]pyridin-5-one

Chemical Property of 3-methyl-1,4-diphenyl-7-thioxo-4,6,8,9-tetrahydropyrazolo[5,4-b]pyrimidino[5,4-e]pyridin-5-one

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Technology Process of 3-methyl-1,4-diphenyl-7-thioxo-4,6,8,9-tetrahydropyrazolo[5,4-b]pyrimidino[5,4-e]pyridin-5-one

There total 2 articles about 3-methyl-1,4-diphenyl-7-thioxo-4,6,8,9-tetrahydropyrazolo[5,4-b]pyrimidino[5,4-e]pyridin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

4,6-dihydroxy-2-mercaptopyrimidine (504-17-6,157796-99-1,924832-30-4) + 3-Aminocrotononitrile (1118-61-2) + benzaldehyde (100-52-7) + phenylhydrazine (100-63-0) → 3-methyl-1,4-diphenyl-7-thioxo-4,6,8,9-tetrahydropyrazolo[5,4-b]pyrimidino[5,4-e]pyridin-5-one (1426333-78-9)

Guidance literature:

With toluene-4-sulfonic acid; In water; at 100 ℃; for 1h;

DOI:10.3390/molecules171214464

Reference yield: 66.0%

4,6-dihydroxy-2-mercaptopyrimidine (504-17-6,157796-99-1,924832-30-4) + 1-Phenyl-3-methyl-5-aminopyrazole (1131-18-6) + benzaldehyde (100-52-7) → 3-methyl-1,4-diphenyl-7-thioxo-4,6,8,9-tetrahydropyrazolo[5,4-b]pyrimidino[5,4-e]pyridin-5-one (1426333-78-9)

Guidance literature:

With toluene-4-sulfonic acid; at 100 ℃; for 10h;

DOI:10.3390/molecules171214464

Reference yield: 72.0%

3-methyl-1,4-diphenyl-7-thioxo-4,6,8,9-tetrahydropyrazolo[5,4-b]pyrimidino[5,4-e]pyridin-5-one (1426333-78-9) + ethyl iodide (75-03-6) → 7-ethylthio-3-methyl-1,4-diphenyl-4,6,9-trihydropyrazolo[5,4-b]pyrimidino[5,4-e]pyridin-5-one (1426333-79-0)

Guidance literature:

With sodium acetate; In ethanol; for 4h; Reflux;

DOI:10.3390/molecules171214464

upstream raw materials:

4,6-dihydroxy-2-mercaptopyrimidine

3-Aminocrotononitrile

benzaldehyde

phenylhydrazine

Downstream raw materials:

8-ethyl-7-ethylthio-3-methyl-1,4-diphenyl-4,6,9-trihydropyrazolo[5,4-b]pyrimidino[5,4-e]pyridin-5-one

6-ethyl-7-ethylthio-3-methyl-1,4-diphenyl-4,6,9-trihydropyrazolo[5,4-b]pyrimidino[5,4-e]pyridin-5-one

7-ethylthio-3-methyl-1,4-diphenyl-4,6,9-trihydropyrazolo[5,4-b]pyrimidino[5,4-e]pyridin-5-one

ethyl 2-(3-methyl-5-oxo-1,4-diphenyl-4,6,9-trihydro-pyrazolo[5,4-b]pyrimidino[5,4-e]pyridin-7-ylthio)acetate

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