1-(4-Methoxyphenyl)-1-phenylethanol

Base Information

• Chemical Name: 1-(4-Methoxyphenyl)-1-phenylethanol
• CAS No.: 94001-65-7
• Molecular Formula: C15H16O2
• Molecular Weight: 228.291
• DSSTox Substance ID: DTXSID10380224
• Nikkaji Number: J1.631.020D
• Mol file: 94001-65-7.mol

Synonyms:1-(4-methoxyphenyl)-1-phenylethanol;94001-65-7;2,6-Di(chloromethyl)pyridine hcl;1-(4-methoxy-phenyl)-1-phenyl-ethanol;1-(4-methoxyphenyl)-1-phenylethan-1-ol;SCHEMBL9906174;AMY2364;DTXSID10380224;4-Methoxyphenyl-methylphenyLcarbinol;AKOS005766937;AC-22544;FT-0737115;A846883

Chemical Property of 1-(4-Methoxyphenyl)-1-phenylethanol

Chemical Property:

• Vapor Pressure: 3.52E-06mmHg at 25°C
• Refractive Index: 1.568
• Boiling Point: 371.6 °C at 760 mmHg
• Flash Point: 164.9 °C
• PSA: 29.46000
• Density: 1.099 g/cm³
• LogP: 2.95100
• Storage Temp.: 2-8°C
• XLogP3: 2.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 228.115029749
• Heavy Atom Count: 17
• Complexity: 227

Purity/Quality:

97% ^*data from raw suppliers

1-(4-Methoxyphenyl)-1-phenylethanol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C1=CC=CC=C1)(C2=CC=C(C=C2)OC)O

Technology Process of 1-(4-Methoxyphenyl)-1-phenylethanol

There total 23 articles about 1-(4-Methoxyphenyl)-1-phenylethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

1-bromo-4-methoxy-benzene (104-92-7) + acetophenone (98-86-2) → 1-(4-methoxyphenyl)-1-phenylethan-1-ol (94001-65-7)

Guidance literature:

1-bromo-4-methoxy-benzene; With magnesium; In diethyl ether;

acetophenone; In diethyl ether; for 2h; Further stages.; Heating;

DOI:10.1002/ejoc.200400140

Reference yield: 89.0%

acetophenone (98-86-2) + 4-methoxyphenyl magnesium bromide (13139-86-1) → 1-(4-methoxyphenyl)-1-phenylethan-1-ol (94001-65-7)

Guidance literature:

4-methoxyphenyl magnesium bromide; With Et₂AlBr; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

With titanium(IV) isopropylate; (S)-[1,1']-binaphthalenyl-2,2'-diol; In toluene; at 0 ℃; for 0.5h; Inert atmosphere;

acetophenone; Further stages;

DOI:10.1021/jo900348p

Reference yield: 89.0%

rac-1-(4-methoxyphenyl)-ethanol (3319-15-1) + 5,5-dimethyl-2-phenyl-1,3,2-dioxaborinane (5123-13-7) → 1-(4-methoxyphenyl)-1-phenylethan-1-ol (94001-65-7)

Guidance literature:

With bis(1,5-cyclooctadiene)nickel ⁽⁰⁾; potassium tert-butylate; chlorobenzene; cesium fluoride; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; In toluene; at 80 ℃; for 5h; Inert atmosphere;

DOI:10.1039/c1cc10826c

upstream raw materials:

acetophenone

4-methoxyphenyl magnesium bromide

1-(4-methoxyphenyl)ethanone

4-Methoxybenzophenone

Downstream raw materials:

1-(4-methoxyphenyl)-1-phenylethene

4-Nitro-benzoic acid 1-(4-methoxy-phenyl)-1-phenyl-ethyl ester

1-methoxy-4-(1-phenylethyl)benzene

(R)-1-(4-methoxyphenyl)-1-phenylethane