ETHYL 2-[(4-CHLOROPHENYL)SULPHONYL]ACETATE

Base Information

• Chemical Name: ETHYL 2-[(4-CHLOROPHENYL)SULPHONYL]ACETATE
• CAS No.: 3636-65-5
• Molecular Formula: C10H11 Cl O4 S
• Molecular Weight: 262.714
• Hs Code.: 2916399090
• Mol file: 3636-65-5.mol

Synonyms:Aceticacid, [(4-chlorophenyl)sulfonyl]-, ethyl ester (9CI); Acetic acid,[(p-chlorophenyl)sulfonyl]-, ethyl ester (7CI,8CI)

Chemical Property of ETHYL 2-[(4-CHLOROPHENYL)SULPHONYL]ACETATE

Chemical Property:

• Vapor Pressure: 6.84E-07mmHg at 25°C
• Melting Point: 55 °C(Solv: ethanol (64-17-5))
• Boiling Point: 179-180/2mm
• Flash Point: 201oC
• PSA: 68.82000
• Density: 1.339g/cm3
• LogP: 2.75760

Purity/Quality:

98% ^*data from raw suppliers

Ethyl [(4-chlorophenyl)sulfonyl]acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2-[(4-CHLOROPHENYL)SULPHONYL]ACETATE

There total 13 articles about ETHYL 2-[(4-CHLOROPHENYL)SULPHONYL]ACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

chloroacetic acid ethyl ester (105-39-5) + 4-chlorobenzenesulfonyl chloride (98-60-2) → ethyl 2-((4-chlorophenyl)sulfonyl)acetate (3636-65-5)

Guidance literature:

4-chlorobenzenesulfonyl chloride; With magnesium; In tetrahydrofuran; at 25 ℃; for 1h; Inert atmosphere; Schlenk technique; Sonication;

chloroacetic acid ethyl ester; With sodium iodide; In tetrahydrofuran; dimethyl sulfoxide; at 60 ℃; for 1h; Inert atmosphere; Schlenk technique; Sonication;

DOI:10.1039/c7ob00251c

Reference yield: 85.0%

sodium p-chlorobenzenesulphinate (14752-66-0) + ethyl acetoacetate (141-97-9) → ethyl 2-((4-chlorophenyl)sulfonyl)acetate (3636-65-5)

Guidance literature:

With ammonium iodide; In dimethyl sulfoxide; at 20 ℃; for 7h; Electrolysis;

DOI:10.1016/j.tet.2015.06.063

Reference yield: 78.0%

diazoacetic acid ethyl ester (623-73-4) + p-chlorophenylsulfonyl hydrazide (2751-25-9) → ethyl 2-((4-chlorophenyl)sulfonyl)acetate (3636-65-5)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; In isopropyl alcohol; at 80 ℃; for 24h;

DOI:10.1021/acs.orglett.6b02532

upstream raw materials:

ethyl bromide

2-(4-chloro-phenylsulfonyl)acetic acid

ethanol

ethyl 2-(p-chlorophenylthio)acetate

Downstream raw materials:

2-(4-chloro-benzenesulfonyl)-2-methyl-propionic acid ethyl ester

3,4-bis(4-chlorobenzene-1-sulfonyl)furoxan