Methyl-(2-methyl-thiazol-4-ylmethyl)-amine

Base Information

• Chemical Name: Methyl-(2-methyl-thiazol-4-ylmethyl)-amine
• CAS No.: 144163-81-5
• Molecular Formula: C₆H₁₀N₂S
• Molecular Weight: 142.225
• Hs Code.: 2934100090
• European Community (EC) Number: 842-416-2
• ChEMBL ID: CHEMBL4559577
• DSSTox Substance ID: DTXSID80596678
• Wikidata: Q82491991
• Mol file: 144163-81-5.mol

Synonyms:144163-81-5;Methyl-(2-methyl-thiazol-4-ylmethyl)-amine;N-methyl-1-(2-methylthiazol-4-yl)methanamine;Methyl-(2-methylthiazole-4-yl methyl)amine;N-METHYL-1-(2-METHYL-1,3-THIAZOL-4-YL)METHANAMINE;4-Thiazolemethanamine, N,2-dimethyl-;methyl[(2-methyl-1,3-thiazol-4-yl)methyl]amine;N,2-Dimethyl-4- thiazolemethanamine;4-Thiazolemethanamine,N,2-dimethyl-;N-Methyl(2-methylthiazol-4-yl)methanamine;N,2-DIMETHYL-(1,3-THIAZOL-4-YL)METHYLAMINE;SCHEMBL1058822;CHEMBL4559577;DTXSID80596678;GJHOBSIOQKGKSG-UHFFFAOYSA-N;MFCD06738964;AKOS009024002;AB28276;(R)-Benzyl 2-bromo-3-phenylpropionate;AM100247;AS-48396;Methyl-(2-methylthiazole-4-ylmethyl)amine;CS-0054974;EN300-27495;F30719;2-Methyl-4-[(methylamino)methyl]-1,3-thiazole;N-methyl(2-methyl-1,3-thiazol-4-yl)methanamine;A808182;W-205603;Z102767814

Chemical Property of Methyl-(2-methyl-thiazol-4-ylmethyl)-amine

Chemical Property:

• Vapor Pressure: 0.229mmHg at 25°C
• Refractive Index: 1.538
• Boiling Point: 207.1 °C at 760 mmHg
• PKA: 8.10±0.10(Predicted)
• Flash Point: 79.1 °C
• PSA: 53.16000
• Density: 1.093 g/cm³
• LogP: 1.56180
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 142.05646950
• Heavy Atom Count: 9
• Complexity: 87.1

Purity/Quality:

98%min ^*data from raw suppliers

N-Methyl-1-(2-methylthiazol-4-yl)methanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=CS1)CNC

Technology Process of Methyl-(2-methyl-thiazol-4-ylmethyl)-amine

There total 3 articles about Methyl-(2-methyl-thiazol-4-ylmethyl)-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-(chloromethyl)-2-methyl-1,3-thiazole (39238-07-8) + methylamine (74-89-5) → N-methyl-(2-methyl-1,3-thiazol-4-yl)methanamine (144163-81-5)

Guidance literature:

at 25 ℃; for 1h;

Reference yield:

4-chloromethyl-2-methylthiazole hydrochloride (77470-53-2) + methylamine (74-89-5) → N-methyl-(2-methyl-1,3-thiazol-4-yl)methanamine (144163-81-5)

Guidance literature:

In water;

DOI:10.1021/jm970636+

Reference yield:

thioacetamide (62-55-5) + 1,3-Dichloroacetone (534-07-6) + methylamine (74-89-5) → N-methyl-(2-methyl-1,3-thiazol-4-yl)methanamine (144163-81-5)

Guidance literature:

thioacetamide; 1,3-Dichloroacetone; With magnesium sulfate; In acetone; Reflux;

methylamine;

DOI:10.1016/j.bmcl.2013.12.057

upstream raw materials:

4-chloromethyl-2-methylthiazole hydrochloride

methylamine

4-(chloromethyl)-2-methyl-1,3-thiazole

thioacetamide

Refernces

• 1、 -. "OXADIAZOLE COMPOUNDS WHICH INHIBIT BETA-SECRETASE ACTIVITY AND METHODS OF USE THEREOF". Page/Page column 84. . Retrieved 2012/05/05.
• 2、 -. "MODULATORS OF PHARMACOKINETIC PROPERTIES OF THERAPEUTICS". Page/Page column 248. . Retrieved 2008/06/13.