2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine

Base Information

• Chemical Name: 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine
• CAS No.: 109205-71-2
• Molecular Formula: C₃₉H₃₈N₄O₁₀
• Molecular Weight: 722.752

Synonyms:2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine

Chemical Property of 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine

There total 1 articles about 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

4,4'-dimethoxytrityl chloride (40615-36-9) + 2'-deoxy-N4-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine (88091-67-2) → 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N4-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine (109205-71-2)

Guidance literature:

With dmap; triethylamine; In pyridine; for 5h; Ambient temperature;

DOI:10.1002/hlca.19980810106

Reference yield: 98.0%

tert-butyldimethylsilyl chloride (18162-48-6) + 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N4-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine (109205-71-2) → {1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid 2-(4-nitro-phenyl)-ethyl ester (109205-75-6)

Guidance literature:

With 1H-imidazole; In pyridine; for 18h; Ambient temperature;

DOI:10.1002/hlca.19980810106

Reference yield: 91.0%

2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N4-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine (109205-71-2) + 2-(4-nitrophenyl)ethyl diisopropylphosphoramidochloridite (153120-90-2) → 5'-O-dimethoxytrityl-3'-O-[2-(4-nitrophenyl)ethoxy-N,N-diisopropyl]-2'-deoxy-N4-[2-(4-nitrophenyl)ethoxycarbonyl]cytidine phosphoramidite

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1002/(SICI)1522-2675(19991215)82:12<2172::AID-HLCA2172>3.0.CO;2-R

upstream raw materials:

4,4'-dimethoxytrityl chloride

2'-deoxy-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine

Downstream raw materials:

4-[2-((2R,3S,5R)-2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-{4-[2-(4-nitro-phenyl)-ethoxycarbonylamino]-2-oxo-2H-pyrimidin-1-yl}-tetrahydro-furan-3-yloxycarbonyloxy)-ethyl]-3-nitro-benzoic acid methyl ester

{1-[(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-carbamic acid 2-(4-nitro-phenyl)-ethyl ester

4-Amino-1-[(2R,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-1H-pyrimidin-2-one

2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine 3'-(hydrogen butanedioate)

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 109205-71-2 2'-deoxy-5'-O-(4,4'-dimethoxytrityl)-N⁴-{[2-(4-nitrophenyl)ethoxy]carbonyl}cytidine

Send

Send

Metric Ton KG G Pound L ML

Send

Send