4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-1-(tert-butyldimethylsilyloxy-methyl)-2-trifluoromethoxybenzene

Base Information

Chemical Name:4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-1-(tert-butyldimethylsilyloxy-methyl)-2-trifluoromethoxybenzene
CAS No.:220996-84-9
Molecular Formula:C₂₄H₃₈F₃NO₅Si
Molecular Weight:505.65
Hs Code.:

Synonyms:4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-1-(tert-butyldimethylsilyloxy-methyl)-2-trifluoromethoxybenzene

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Chemical Property of 4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-1-(tert-butyldimethylsilyloxy-methyl)-2-trifluoromethoxybenzene

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Technology Process of 4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-1-(tert-butyldimethylsilyloxy-methyl)-2-trifluoromethoxybenzene

There total 4 articles about 4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-1-(tert-butyldimethylsilyloxy-methyl)-2-trifluoromethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 109384-19-2
t-butyl 4-hydroxy piperidine-1-carboxylate

: 220996-83-8
4-hydroxy-1-(tert-butyldimethyl-silyloxymethyl)-2-trifluoromethoxybenzene

: 220996-84-9
4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-1-(tert-butyldimethylsilyloxy-methyl)-2-trifluoromethoxybenzene

Guidance literature:: With triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran;
DOI:10.1016/S0960-894X(99)00181-X

Reference yield:

: 220996-81-6
(4-bromo-2-(trifluoromethoxy)phenyl)methanol

: 220996-84-9
4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-1-(tert-butyldimethylsilyloxy-methyl)-2-trifluoromethoxybenzene

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / 4-(dimethylamino)pyridine / CH₂Cl₂

2: 1.) n-BuLi, 2.) B(OMe)3, 3.) H₂O₂, HOAc

3: diethyl azodicarboxylate, Ph₃P / tetrahydrofuran

With dmap; n-butyllithium; Trimethyl borate; dihydrogen peroxide; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane;
DOI:10.1016/S0960-894X(99)00181-X

Reference yield:

: 4-bromo-1-iodo-2-(trifluormethoxy)benzene

: 220996-84-9
4-(N-tert-butyloxycarbonyl-4-piperidinyloxy)-1-(tert-butyldimethylsilyloxy-methyl)-2-trifluoromethoxybenzene

Guidance literature:: Multi-step reaction with 5 steps

1: 85 percent / n-BuLi / tetrahydrofuran

2: 95 percent / NaBH₄ / methanol

3: 95 percent / 4-(dimethylamino)pyridine / CH₂Cl₂

4: 1.) n-BuLi, 2.) B(OMe)3, 3.) H₂O₂, HOAc

5: diethyl azodicarboxylate, Ph₃P / tetrahydrofuran

With dmap; sodium tetrahydroborate; n-butyllithium; Trimethyl borate; dihydrogen peroxide; acetic acid; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/S0960-894X(99)00181-X