BENZYL 4-(4-(METHOXYCARBONYL)PHENYLAMINO)PIPERIDINE-1-CARBOXYLATE

Base Information

• Chemical Name: BENZYL 4-(4-(METHOXYCARBONYL)PHENYLAMINO)PIPERIDINE-1-CARBOXYLATE
• CAS No.: 1037834-44-8
• Molecular Formula: C₂₁H₂₄N₂O₄
• Molecular Weight: 368.433
• Mol file: 1037834-44-8.mol

Synonyms:benzyl 4-(4-(methoxycarbonyl)-phenylamino)piperidine-1-carboxylate

Chemical Property of BENZYL 4-(4-(METHOXYCARBONYL)PHENYLAMINO)PIPERIDINE-1-CARBOXYLATE

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Benzyl4-((4-(methoxycarbonyl)phenyl)amino)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

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Technology Process of BENZYL 4-(4-(METHOXYCARBONYL)PHENYLAMINO)PIPERIDINE-1-CARBOXYLATE

There total 2 articles about BENZYL 4-(4-(METHOXYCARBONYL)PHENYLAMINO)PIPERIDINE-1-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

benzyl 4-oxo-1-piperidinecarboxylate (19099-93-5) + 4-methoxycarbonyl aniline (619-45-4) → 1-(benzyloxycarbonyl)-4-hydroxypiperidine (95798-23-5) + benzyl 4-(4-(methoxycarbonyl)-phenylamino)piperidine-1-carboxylate (1037834-44-8)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In dichloromethane; at 22 - 27 ℃; for 18h; Inert atmosphere;

DOI:10.15227/orgsyn.090.0074

Reference yield: 86.0%

benzyl 4-oxo-1-piperidinecarboxylate (19099-93-5) + 4-methoxycarbonyl aniline (619-45-4) → benzyl 4-(4-(methoxycarbonyl)-phenylamino)piperidine-1-carboxylate (1037834-44-8)

Guidance literature:

With sodium triacetoxy borohydride; acetic acid; In dichloromethane; at 15 - 25 ℃; for 4h; Large scale reaction;

DOI:10.1021/op200332p

Reference yield: 94.0%

benzyl 4-(4-(methoxycarbonyl)-phenylamino)piperidine-1-carboxylate (1037834-44-8) + chloroacetyl chloride (79-04-9) → benzyl 4-(2-chloro-N-(4-(methoxycarbonyl)phenyl)acetamido)-piperidine-1-carboxylate (1037834-45-9)

Guidance literature:

With pyridine; In ethyl acetate; at 3 - 20 ℃; for 1.5h; Inert atmosphere;

DOI:10.15227/orgsyn.090.0074

upstream raw materials:

benzyl 4-oxo-1-piperidinecarboxylate

4-methoxycarbonyl aniline

Downstream raw materials:

benzyl 4-(2-chloro-N-(4-(methoxycarbonyl)phenyl)acetamido)-piperidine-1-carboxylate

methyl 1-(1-(benzyloxycarbonyl)-piperidin-4-yl)-2-oxoindoline-5-carboxylate

1-{1-[(benzyloxy)carbonyl]piperidin-4-yl}-2-oxoindoline-5-carboxylic acid

benzyl 4-{5-[(methylamino)carbonyl]-2-oxo-2,3-dihydro-1H-indol-1-yl}piperidine-1-carboxylate

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