4-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)-2-nitrobenzonitrile tosylate

Base Information

Chemical Name:4-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)-2-nitrobenzonitrile tosylate
CAS No.:1027345-31-8
Molecular Formula:C₇H₈O₃S*C₂₄H₂₁ClN₄O₂
Molecular Weight:605.114
Hs Code.:

Synonyms:4-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)-2-nitrobenzonitrile tosylate

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Chemical Property of 4-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)-2-nitrobenzonitrile tosylate

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Technology Process of 4-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)-2-nitrobenzonitrile tosylate

There total 6 articles about 4-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)-2-nitrobenzonitrile tosylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1027345-29-4
4-(4-(2-bromobenzyl)piperazin-1-yl)-2-nitrobenzonitrile

: 1679-18-1
4-Chlorophenylboronic acid

: 104-15-4
toluene-4-sulfonic acid

: 1027345-31-8
4-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)-2-nitrobenzonitrile tosylate

Guidance literature:: 4-(4-(2-bromobenzyl)piperazin-1-yl)-2-nitrobenzonitrile; 4-Chlorophenylboronic acid; With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,2-dimethoxyethane; ethanol; water; at 90 ℃; for 4h; Inert atmosphere;

toluene-4-sulfonic acid; In diethyl ether; acetonitrile; Inert atmosphere;
DOI:10.1021/jm101596e

Reference yield:

: 1027345-30-7
C₂₄H₂₁ClN₄O₂

: 104-15-4
toluene-4-sulfonic acid

: 1027345-31-8
4-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)-2-nitrobenzonitrile tosylate

Guidance literature:: In diethyl ether; acetonitrile;

Reference yield:

: 4110-33-2
2,4-dinitrobenzonitrile

: 1027345-31-8
4-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)-2-nitrobenzonitrile tosylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: dimethyl sulfoxide / 72 h / 25 °C / Inert atmosphere

2.1: acetonitrile / 2 h / Inert atmosphere

3.1: triethylamine / isopropyl alcohol / 3 h / Inert atmosphere

4.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 4 h / 90 °C / Inert atmosphere

4.2: Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; triethylamine; In 1,2-dimethoxyethane; ethanol; water; dimethyl sulfoxide; isopropyl alcohol; acetonitrile; 4.1: Suzuki coupling;
DOI:10.1021/jm101596e